(Z)-4EGI-1
|
|
- CAS号:
- 901787-88-0
- 英文名:
- OTAVA-BB 7070707011
- 英文别名:
- (Z)-4EGI-1;OTAVA-BB 7070707011;(Z)4EGI1,(Z) 4EGI 1;Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-, (αZ)-
- 中文名:
- (Z)-4EGI-1
- 中文别名:
- CBNumber:
- CB62459208
- 分子式:
- C18H12Cl2N4O4S
- 分子量:
- 451.28
- MOL File:
- 901787-88-0.mol
|
|
|
(Z)-4EGI-1化学性质
-
沸点:
-
668.9±65.0 °C(Predicted)
-
|
-
密度:
-
1.58±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: 50 mg/mL (110.80 mM; ultrasonic and warming and heat to 60°C)
-
|
-
酸度系数(pKa):
-
0.71±0.41(Predicted)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
Light brown to gray
-
|
(Z)-4EGI-1性质、用途与生产工艺
(Z)-4EGI-1 是 4EGI-1 的 Z-型异构体,是 eIF4E/eIF4G 相互作用和翻译起始的抑制剂。(Z)-4EGI-1 有效结合 eIF4E ,IC50 为 43.5 μM,Kd 值为 8.74 μM。(Z)-4EGI-1 具有抗癌活性。
IC50: 43.5 μM (eIF4E)
Kd: 8.74 μM (eIF4E)
(Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected.
(Z)-4EGI-1 inhibits cancer cells proliferation with IC
50
values of 15.3 μM and 11.6 μM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively.
Western Blot Analysis
Cell Line:
|
CRL-2813 melanoma cells
|
Concentration:
|
15 µM, 30 µM
|
Incubation Time:
|
6 hours
|
Result:
|
Markedly reduced the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin.
|
(Z)-4EGI-1
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-19831A | (Z)-4EGI-1 | | 1 mg | 1136元 |
2024/04/30 | HY-19831A | (Z)-4EGI-1 | 901787-88-0 | 5mg | 2500元 |
901787-88-0, (Z)-4EGI-1 相关搜索:
- 901787-88-0
- Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-, (αZ)-
- (Z)4EGI1,(Z) 4EGI 1
- (Z)-4EGI-1
- OTAVA-BB 7070707011