(Z)-4EGI-1
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- CAS号:
- 901787-88-0
- 英文名:
- OTAVA-BB 7070707011
- 英文别名:
- (Z)-4EGI-1;OTAVA-BB 7070707011;(Z)4EGI1,(Z) 4EGI 1;Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-, (αZ)-
- 中文名:
- (Z)-4EGI-1
- 中文别名:
- CBNumber:
- CB62459208
- 分子式:
- C18H12Cl2N4O4S
- 分子量:
- 451.28
- MOL File:
- 901787-88-0.mol
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(Z)-4EGI-1化学性质
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沸点:
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668.9±65.0 °C(Predicted)
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密度:
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1.58±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 50 mg/mL (110.80 mM; ultrasonic and warming and heat to 60°C)
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酸度系数(pKa):
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0.71±0.41(Predicted)
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形态:
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Solid
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颜色:
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Light brown to gray
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(Z)-4EGI-1性质、用途与生产工艺
(Z)-4EGI-1 是 4EGI-1 的 Z-型异构体，是 eIF4E/eIF4G 相互作用和翻译起始的抑制剂。(Z)-4EGI-1 有效结合 eIF4E ，IC50 为 43.5 μM，Kd 值为 8.74 μM。(Z)-4EGI-1 具有抗癌活性。
IC50: 43.5 μM (eIF4E)
Kd: 8.74 μM (eIF4E)
(Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected.
(Z)-4EGI-1 inhibits cancer cells proliferation with IC
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values of 15.3 μM and 11.6 μM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively.
Western Blot Analysis
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Cell Line:
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CRL-2813 melanoma cells
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Concentration:
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15 µM, 30 µM
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Incubation Time:
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6 hours
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Result:
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Markedly reduced the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin.
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(Z)-4EGI-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-19831A | (Z)-4EGI-1 | | 1 mg | 1136元 |
| 2024/04/30 | HY-19831A | (Z)-4EGI-1 | 901787-88-0 | 5mg | 2500元 |
901787-88-0, (Z)-4EGI-1 相关搜索:
- 901787-88-0
- Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-, (αZ)-
- (Z)4EGI1,(Z) 4EGI 1
- (Z)-4EGI-1
- OTAVA-BB 7070707011