(Z)-4EGI-1
中文名称 | (Z)-4EGI-1 |
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中文同义词 | |
英文名称 | OTAVA-BB 7070707011 |
英文同义词 | OTAVA-BB 7070707011;(Z)-4EGI-1;(Z)4EGI1,(Z) 4EGI 1;Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-, (αZ)- |
CAS号 | 901787-88-0 |
分子式 | C18H12Cl2N4O4S |
分子量 | 451.28 |
EINECS号 | |
相关类别 | |
Mol文件 | 901787-88-0.mol |
结构式 | ![]() |
(Z)-4EGI-1 性质
沸点 | 668.9±65.0 °C(Predicted) |
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密度 | 1.58±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:50 mg/mL(110.80 mM;超声加热并加热至 60°C) |
酸度系数(pKa) | 0.71±0.41(Predicted) |
形态 | 固体 |
颜色 | 浅棕色至灰色 |
IC50: 43.5 μM (eIF4E)
Kd: 8.74 μM (eIF4E)
(Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected.
(Z)-4EGI-1 inhibits cancer cells proliferation with IC
50
values of 15.3 μM and 11.6 μM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively.
Western Blot Analysis
Cell Line: | CRL-2813 melanoma cells |
Concentration: | 15 µM, 30 µM |
Incubation Time: | 6 hours |
Result: | Markedly reduced the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-19831A | (Z)-4EGI-1 | 1 mg | 1136元 | |
2024/04/30 | HY-19831A | (Z)-4EGI-1 | 901787-88-0 | 5mg | 2500元 |