1160247-92-6
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- CAS号:
- 1160247-92-6
- 英文名:
- 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin
- 英文别名:
- VU 0238429;1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin;1-(4-Methoxybenzyl)-5-(trifluoromethoxy)indoline-2,3-dione;1-(4-Methoxy-benzyl)-5-trifluoromethoxy-1H-indole-2,3-dione;1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione;1H-Indole-2,3-dione, 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-;VU 0238429,VU-0238429,Muscarinic acetylcholine receptor,Inhibitor,inhibit,mAChR
- 中文名:
- 1160247-92-6
- 中文别名:
- 化合物VU0238429;VU 0238429,正变构M 5调节剂;1-(4-甲氧基苄基)-5-(三氟甲氧基)二氢吲哚-2,3-二酮
- CBNumber:
- CB62518758
- 分子式:
- C17H12F3NO4
- 分子量:
- 351.28
- MOL File:
- 1160247-92-6.mol
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1160247-92-6化学性质
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沸点:
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459.7±55.0 °C(Predicted)
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密度:
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1.432±0.06 g/cm3(Predicted)
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储存条件:
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Inert atmosphere,2-8°C
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溶解度:
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DMSO: ≥20mg/mL
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酸度系数(pKa):
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-3.68±0.20(Predicted)
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形态:
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powder
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颜色:
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orange
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1160247-92-6性质、用途与生产工艺
VU0238429 (M5 PAM)是第一个 muscarinic acetylcholine receptor subtype 5 (mAChR5/M5) 的阳性变构调节剂，对于M5的EC50值为 1.16 μM，而对于M1和M3的EC50均大于 30 μM。VU0238429 对于M2和M4没有显现出增强剂的活性。
| Target | Value |
M1 mAChR
()
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M3 mAChR
()
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M5 mAChR
(Cell-free assay)
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1.16 μM
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VU 0238429 is positive allosteric modulator of mAChR5 (M5), with an
EC
50
of 1.16 μM, >30-fold selectivity versus M1 and M3, with no M2 or M4 potentiator activity.
1160247-92-6
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-12157 | 1160247-92-6
VU 0238429 | 1160247-92-6 | 5mg | 600元 |
| 2024/11/08 | HY-12157 | 1160247-92-6
VU 0238429 | 1160247-92-6 | 10mM * 1mLin DMSO | 660元 |
1160247-92-6, 1160247-92-6 相关搜索:
- 抑制剂
- 合成有机化合物配体
- VU 0238429,正变构M 5调节剂
- 化合物VU0238429
- 1-(4-甲氧基苄基)-5-(三氟甲氧基)二氢吲哚-2,3-二酮
- 1160247-92-6
- VU 0238429,VU-0238429,Muscarinic acetylcholine receptor,Inhibitor,inhibit,mAChR
- 1-(4-Methoxybenzyl)-5-(trifluoromethoxy)indoline-2,3-dione
- 1H-Indole-2,3-dione, 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-
- 1-(4-Methoxy-benzyl)-5-trifluoromethoxy-1H-indole-2,3-dione
- 1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
- VU 0238429
- 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin