883031-03-6
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- CAS号:
- 883031-03-6
- 英文名:
- 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
- 英文别名:
- HC 067047;HC-067047 >=98% (HPLC);HC-067047;HC 067047;HC067047;1221277-90-2;Transient receptor potential channels,HC-067047,Inhibitor,HC 067047,TRP Channel,inhibit;2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide;2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide;1H-Pyrrole-3-carboxamide, 2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-
- 中文名:
- 883031-03-6
- 中文别名:
- 化合物HC-067047;HC 067047,可逆TRPV4拮抗剂
- CBNumber:
- CB62518965
- 分子式:
- C26H28F3N3O2
- 分子量:
- 471.51
- MOL File:
- 883031-03-6.mol
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883031-03-6化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥15mg/mL
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形态:
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powder
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颜色:
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white to tan
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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883031-03-6性质、用途与生产工艺
HC-067047是一种选择性的TRPV4拮抗剂，对人TRPV4，大鼠TRPV4和小鼠TRPV4的IC50分别为48 nM，133 nM和17 nM。
| Target | Value |
mTRPV4
(Cell-free assay)
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17 nM
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hTRPV4
(Cell-free assay)
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48 nM
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rTRPV4
(Cell-free assay)
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133 nM
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HC-067047 (1 µM; 24 hours; HEI-OC1 cells) treatment significantly decreases mRNA expression in high glucose cultured HEI-OC1 cells.
HC-067047 (1 µM; 24 hours; HEI-OC1 cells) treatment significantly decreases the expression of TRPV4 protein.
HC-067047 (1 µM; 48 hours; HEI-OC1 cells) treatment inhibits cell proliferation.
HC-067047 (1 µM; 48 hours; HEI-OC1 cells) treatment promotes cell apoptosis.
RT-PCR
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Cell Line:
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HEI-OC1 cells
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Concentration:
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1 µM
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Incubation Time:
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24 hours
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Result:
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The mRNA expression was significantly decreased.
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Western Blot Analysis
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Cell Line:
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HEI-OC1 cells
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Concentration:
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1 µM
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Incubation Time:
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24 hours
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Result:
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The expression of TRPV4 protein was significantly decreased.
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Cell Proliferation Assay
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Cell Line:
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HEI-OC1 cells
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Concentration:
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1 µM
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Incubation Time:
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48 hours
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Result:
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Inhibited cell proliferation.
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Apoptosis Analysis
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Cell Line:
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HEI-OC1 cells
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Concentration:
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1 µM
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Incubation Time:
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48 hours
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Result:
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Promoted cell apoptosis.
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HC-067047 (0-50 mg/kg; intraperitoneal injection; for 30 minutes; cyclophosphamide-treated WT and Trpv4
−/−
mice, and naive WT mice) treatment increases functional bladder capacity and reduces micturition frequency in WT mice with cystitis. HC-067047 do not affect bladder function in Trpv4
−/−
mice.
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Animal Model:
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Cyclophosphamide-treated WT and Trpv4
−/−
mice, and naive WT mice
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Dosage:
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0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg
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Administration:
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Intraperitoneal injection; for 30 minutes
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Result:
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Increased functional bladder capacity and reduces micturition frequency in WT mice with cystitis and did not affect bladder function in Trpv4
−/−
mice.
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883031-03-6
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100208 | 883031-03-6
HC-067047 | 883031-03-6 | 5mg | 660元 |
| 2024/04/30 | HY-100208 | 883031-03-6
HC-067047 | 883031-03-6 | 10mM * 1mLin DMSO | 685元 |
883031-03-6, 883031-03-6 相关搜索:
- Potent and selective TRPV4 antagonist.
- 合成有机化合物配体
- C26H28F3N3O2
- HC 067047,可逆TRPV4拮抗剂
- 化合物HC-067047
- 883031-03-6
- Transient receptor potential channels,HC-067047,Inhibitor,HC 067047,TRP Channel,inhibit
- HC-067047 >=98% (HPLC)
- 1H-Pyrrole-3-carboxamide, 2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-
- HC-067047;HC 067047;HC067047;1221277-90-2
- 2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide
- HC 067047
- 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide