1160514-60-2
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- CAS号:
- 1160514-60-2
- 英文名:
- 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
- 英文别名:
- Pyr3;Pyr3,Pyr-3;TRPC3 Channel Inhibitor, Pyr3;TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem;Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate;Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate;1-[4-(2,3,3-Trichloro-acryloylamino)-phenyl]-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester;1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid;1H-Pyrazole-4-carboxylic acid, 1-[4-[(2,3,3-trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-, ethyl ester
- 中文名:
- 1160514-60-2
- 中文别名:
- 吡喃 3;化合物PYR3;化合物 T16687;PYR3,TRPC3通道阻止器;1-(4-(2,3,3-三氯丙烯酰胺基)苯基)-5-(三氟甲基)-1H-吡唑-4-羧酸乙酯
- CBNumber:
- CB72518795
- 分子式:
- C16H11Cl3F3N3O3
- 分子量:
- 456.63
- MOL File:
- 1160514-60-2.mol
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1160514-60-2化学性质
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熔点:
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151-153 °C(Solv: toluene (108-88-3))
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沸点:
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534.0±50.0 °C(Predicted)
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密度:
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1.54±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO (up to 40 mg/ml).
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形态:
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powder
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酸度系数(pKa):
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9.97±0.70(Predicted)
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颜色:
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white to beige
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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1160514-60-2性质、用途与生产工艺
Pyr3 是 TRPC3 的选择性抑制剂，其对 TRPC3 介导的 Ca2+ 内流的 IC50 值为 700 nM。
Pyr3 selectively and directly inhibits TRPC3 channels among TRPC family members. Application of Pyr3 inhibits TRPC3-mediated Ca
2+
influx in a dose-dependent manner with the IC
50
value of 700 nM. Pyr3 becomes apparent at 0.3 μM, and is almost complete at 3 μM. Interestingly, Ca
2+
influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells coexpressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3, but weakly by Pyr2 in a concentration-dependent manner (IC
50
value was 0.05 μM for Pyr3 and 2 μM for Pyr2).
1160514-60-2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-108465 | Pyr3 | | 1 mg | 320元 |
| 2024/11/08 | HY-108465 | 1160514-60-2
Pyr3 | 1160514-60-2 | 5mg | 800元 |
1160514-60-2, 1160514-60-2 相关搜索:
- 抑制剂
- 合成有机化合物配体
- PYR3,TRPC3通道阻止器
- 1-(4-(2,3,3-三氯丙烯酰胺基)苯基)-5-(三氟甲基)-1H-吡唑-4-羧酸乙酯
- 化合物PYR3
- 吡喃 3
- 化合物 T16687
- 1160514-60-2
- Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Pyr3,Pyr-3
- Pyr3
- 1H-Pyrazole-4-carboxylic acid, 1-[4-[(2,3,3-trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-, ethyl ester
- TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem
- 1-[4-(2,3,3-Trichloro-acryloylamino)-phenyl]-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester
- TRPC3 Channel Inhibitor, Pyr3
- Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid