1160514-60-2
中文名称 | 1160514-60-2 |
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中文同义词 | 化合物 T16687;吡喃 3;化合物PYR3;1-(4-(2,3,3-三氯丙烯酰胺基)苯基)-5-(三氟甲基)-1H-吡唑-4-羧酸乙酯;PYR3,TRPC3通道阻止器 |
英文名称 | 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid |
英文同义词 | 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid;Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate;TRPC3 Channel Inhibitor, Pyr3;1-[4-(2,3,3-Trichloro-acryloylamino)-phenyl]-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester;TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem;1H-Pyrazole-4-carboxylic acid, 1-[4-[(2,3,3-trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-, ethyl ester;Pyr3;Pyr3,Pyr-3 |
CAS号 | 1160514-60-2 |
分子式 | C16H11Cl3F3N3O3 |
分子量 | 456.63 |
EINECS号 | |
相关类别 | |
Mol文件 | 1160514-60-2.mol |
结构式 |
1160514-60-2 性质
熔点 | 151-153 °C(Solv: toluene (108-88-3)) |
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沸点 | 534.0±50.0 °C(Predicted) |
密度 | 1.54±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于DMSO(高达40mg/ml)。 |
形态 | 粉末 |
酸度系数(pKa) | 9.97±0.70(Predicted) |
颜色 | 白色至米色 |
稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
IC50: 700 nM (TRPC3).
Pyr3 selectively and directly inhibits TRPC3 channels among TRPC family members. Application of Pyr3 inhibits TRPC3-mediated Ca 2+ influx in a dose-dependent manner with the IC 50 value of 700 nM. Pyr3 becomes apparent at 0.3 μM, and is almost complete at 3 μM. Interestingly, Ca 2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells coexpressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3, but weakly by Pyr2 in a concentration-dependent manner (IC 50 value was 0.05 μM for Pyr3 and 2 μM for Pyr2).
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-108465 | Pyr3 | 1 mg | 320元 | |
2024/04/30 | HY-108465 | 1160514-60-2 Pyr3 | 1160514-60-2 | 5mg | 800元 |