2-氨基-5-异丁基-4-[5-膦酰基-2-呋喃基]噻唑
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- CAS号:
- 261365-11-1
- 英文名:
- MB-05032
- 英文别名:
- MB-05032;MB-05032; MB05032;2-Amino-5-isobutyl-4-[5-phosphono-2-furanyl]thiazole;[5-(2-Amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid;P-[5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid;Phosphonic acid, P-[5-[2-amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]-
- 中文名:
- 2-氨基-5-异丁基-4-[5-膦酰基-2-呋喃基]噻唑
- 中文别名:
- 化合物 T16020;化合物 MB05032;MB05032,FBPASE抑制剂;2-氨基-5-异丁基-4-[5-膦酰基-2-呋喃基]噻唑;11-{4-[2-(2-羟乙氧基)-1-哌嗪]}二苯并[B,F][1,4]硫氮杂卓
- CBNumber:
- CB62628073
- 分子式:
- C11H15N2O4PS
- 分子量:
- 302.29
- MOL File:
- 261365-11-1.mol
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2-氨基-5-异丁基-4-[5-膦酰基-2-呋喃基]噻唑化学性质
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沸点:
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576.7±60.0 °C(Predicted)
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密度:
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1.47±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Powder
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酸度系数(pKa):
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0.98±0.10(Predicted)
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颜色:
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Off-white to yellow
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2-氨基-5-异丁基-4-[5-膦酰基-2-呋喃基]噻唑性质、用途与生产工艺
MB05032 是 GNG 抑制剂，能靶向果糖-1，6-双磷酸酯酶的AMP结合位点，IC50为 16 nM。
IC50: 16 nM (Human Liver FBPase)
MB06322 (3/6-300 mg/kg (young/aged Zucker diabetic fatty (ZDF) rats); p.o.; once) results in dose-dependent glucose lowering in young ZDF rats with mild diabetes and aged ZDF rats with overt diabetes.
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Animal Model:
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ZDF rats (8- to 9-week-old (mild diabetes) and 12- to 13-week-old (overt diabetes))
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Dosage:
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3, 6, 10, 30, 300 mg/kg (young ZDF rats); 6, 10, 30, 300 mg/kg (aged ZDF rats)
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Administration:
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Oral administration; once
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Result:
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Results in dose-dependent glucose lowering.
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2-氨基-5-异丁基-4-[5-膦酰基-2-呋喃基]噻唑
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/11/08 | HY-16307 | 2-氨基-5-异丁基-4-[5-膦酰基-2-呋喃基]噻唑
MB05032 | 261365-11-1 | 2mg | 1400元 |
| 2024/11/08 | HY-16307 | 2-氨基-5-异丁基-4-[5-膦酰基-2-呋喃基]噻唑
MB05032 | 261365-11-1 | 5mg | 2200元 |
2-氨基-5-异丁基-4-[5-膦酰基-2-呋喃基]噻唑
生产厂家
261365-11-1, 2-氨基-5-异丁基-4-[5-膦酰基-2-呋喃基]噻唑 相关搜索:
- 抑制剂
- 高端化学
- 化合物 MB05032
- MB05032,FBPASE抑制剂
- 11-{4-[2-(2-羟乙氧基)-1-哌嗪]}二苯并[B,F][1,4]硫氮杂卓
- 化合物 T16020
- 2-氨基-5-异丁基-4-[5-膦酰基-2-呋喃基]噻唑
- 261365-11-1
- Phosphonic acid, P-[5-[2-amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]-
- P-[5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid
- MB-05032; MB05032
- [5-(2-Amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
- 2-Amino-5-isobutyl-4-[5-phosphono-2-furanyl]thiazole
- MB-05032