CPD2802
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- CAS号:
- 186392-65-4
- 英文名:
- N-{(1S,2R)-1-benzyl-3-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-hydroxy-3-oxopropyl}-5-chloro-1H-indole-2-carboxaMide|ingliforib
- 英文别名:
- 296;CP296;CP-296;CP 296;CPD2802;GPi 296;CP368296;CP-368296;CP 368296;Ingliforib
- 中文名:
- CPD2802
- 中文别名:
- 英格利福里布;化合物INGLIFORIB;5-氯-N-((2S,3R)-4-((3R,4S)-3,4-二羟基吡咯烷-1-基)-3-羟基-4-氧代-1-苯基丁烷-2-基)-1H-吲哚-2-甲酰胺
- CBNumber:
- CB62663621
- 分子式:
- C23H24ClN3O5
- 分子量:
- 457.91
- MOL File:
- 186392-65-4.mol
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CPD2802化学性质
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熔点:
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238 °C
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沸点:
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843.3±65.0 °C(Predicted)
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密度:
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1.495±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:130.0(Max Conc. mg/mL);283.9(Max Conc. mM)
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形态:
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Solid
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酸度系数(pKa):
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12.88±0.20(Predicted)
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颜色:
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Light yellow to yellow
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CPD2802性质、用途与生产工艺
Ingliforib 是一种 glycogen phosphorylase 抑制剂,对肝脏、肌肉和大脑 glycogen phosphorylase 的 IC50 值分别为 52,352 和 150 nM,具有心脏保护的作用。
IC50: 52 nM (liver Glycogen phosphorylase), 352 nM (Muscle Glycogen phosphorylase), 150 nM (Barin Glycogen phosphorylase)
Ingliforib is a glycogen phosphorylase inhibitor, and inhibits the myocardial GP isoforms (muscle and brain) with IC
50
s of 352 and 150 nM, respectively, also a potent inhibitor of the liver isoform (IC
50
of 52 nM). Ingliforib (0.1, 1, 10 μM) dose-dependently reduces infarct size in the isolated rabbit hearts.
Ingliforib (15 mg/kg) potently reduces infarct size by 52%, and decreases plasma glucose and lactate concentrations in openchest anesthetized rabbits. Ingliforib (15 mg/kg) also inhibits myocardial glycogen phosphorylase a (GPa) and total glycogen phosphorylase (GP) activity in anesthetized rabbits.
CPD2802
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-19396 | Ingliforib | | 1 mg | 1180元 |
2024/04/30 | HY-19396 | CPD2802 Ingliforib | 186392-65-4 | 5mg | 2380元 |
186392-65-4, CPD2802 相关搜索:
- APIs
- peptides
- 药靶配体
- 英格利福里布
- 5-氯-N-((2S,3R)-4-((3R,4S)-3,4-二羟基吡咯烷-1-基)-3-羟基-4-氧代-1-苯基丁烷-2-基)-1H-吲哚-2-甲酰胺
- 化合物INGLIFORIB
- 186392-65-4
- 5-Chloro-N-((2S,3R)-4-((3R,4S)-3,4-dihydroxypyrrolidin-1-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-1H-indole-2-carboxamide
- Inhibitor,GPi296,GPi-296,CP368296,CP-368296,Ingliforib,inhibit
- 1H-Indole-2-carboxamide, 5-chloro-N-[(1S,2R)-3-[(3R,4S)-3,4-dihydroxy-1-pyrrolidinyl]-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-
- 5-chloro-N-((2S,3R)-4-((3S,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-1H-indole-2-carboxamide
- GPi 296
- Ingliforib (CP 368296
- Ingliforib
- CPD2802
- INGLIFORIB; CP-296; CP-368; CP-368;296; CP296; CP 296; CP-368296; CP368296; CP 368296
- CP-368296
- CP368296
- CP-296
- CP296
- CP 368296
- CP 296
- 296
- N-{(1S,2R)-1-benzyl-3-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-hydroxy-3-oxopropyl}-5-chloro-1H-indole-2-carboxaMide|ingliforib