CPD2802
| 中文名称 | CPD2802 |
|---|---|
| 中文同义词 | 化合物INGLIFORIB;5-氯-N-((2S,3R)-4-((3R,4S)-3,4-二羟基吡咯烷-1-基)-3-羟基-4-氧代-1-苯基丁烷-2-基)-1H-吲哚-2-甲酰胺;英格利福里布 |
| 英文名称 | N-{(1S,2R)-1-benzyl-3-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-hydroxy-3-oxopropyl}-5-chloro-1H-indole-2-carboxaMide|ingliforib |
| 英文同义词 | N-{(1S,2R)-1-benzyl-3-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-hydroxy-3-oxopropyl}-5-chloro-1H-indole-2-carboxaMide|ingliforib;296;CP 296;CP 368296;CP296;CP-296;CP368296;CP-368296 |
| CAS号 | 186392-65-4 |
| 分子式 | C23H24ClN3O5 |
| 分子量 | 457.91 |
| EINECS号 | |
| 相关类别 | peptides;APIs |
| Mol文件 | 186392-65-4.mol |
| 结构式 |  |
CPD2802 性质
| 熔点 | 238 °C |
|---|---|
| 沸点 | 843.3±65.0 °C(Predicted) |
| 密度 | 1.495±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO:130.0(最大浓度 mg/mL);283.9(最大浓度 mM) |
| 形态 | 固体 |
| 酸度系数(pKa) | 12.88±0.20(Predicted) |
| 颜色 | 浅黄至黄色 |
IC50: 52 nM (liver Glycogen phosphorylase), 352 nM (Muscle Glycogen phosphorylase), 150 nM (Barin Glycogen phosphorylase)
Ingliforib is a glycogen phosphorylase inhibitor, and inhibits the myocardial GP isoforms (muscle and brain) with IC 50 s of 352 and 150 nM, respectively, also a potent inhibitor of the liver isoform (IC 50 of 52 nM). Ingliforib (0.1, 1, 10 μM) dose-dependently reduces infarct size in the isolated rabbit hearts.
Ingliforib (15 mg/kg) potently reduces infarct size by 52%, and decreases plasma glucose and lactate concentrations in openchest anesthetized rabbits. Ingliforib (15 mg/kg) also inhibits myocardial glycogen phosphorylase a (GPa) and total glycogen phosphorylase (GP) activity in anesthetized rabbits.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-19396 | Ingliforib | 1 mg | 1180元 | |
| 2024/04/30 | HY-19396 | CPD2802 Ingliforib | 186392-65-4 | 5mg | 2380元 |