CS-2826
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- CAS号:
- 1802637-39-3
- 英文名:
- BB-Cl-Amidine
- 英文别名:
- CS-2826;BB-Cl-Amidine;N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-biphenylcarboxamide;(S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide;Peptidylarginine Deiminase,Inhibitor,BBClAmidine,BB Cl Amidine,Protein Arginine Deiminase,inhibit;[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-
- 中文名:
- CS-2826
- 中文别名:
- 化合物BB-CL-AMIDINE;(S)-N-(1-(1H-苯并[D]咪唑-2-基)-4-(2-氯乙酰亚胺基)丁基)-[1,1'-联苯基]-4-甲酰胺;(S)-N-(1-(1H-苯并[D]咪唑-2-基)-4-(2-氯乙酰亚胺基)丁基)-[1,1'-联苯基]-4-甲酰胺
- CBNumber:
- CB63152560
- 分子式:
- C26H26ClN5O
- 分子量:
- 459.971
- MOL File:
- 1802637-39-3.mol
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CS-2826化学性质
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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DMSO:76.33(Max Conc. mg/mL);165.94(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);43.48(Max Conc. mM) Water:70.0(Max Conc. mg/mL);152.18(Max Conc. mM) Ethanol:54.5(Max Conc. mg/mL);118.48(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.09(Max Conc. mM)-
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形态:
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A crystalline solid
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CS-2826性质、用途与生产工艺
BB-Cl-Amidine 是肽基精氨酸脱胺酶 (PAD) 的抑制剂。
Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely.
Animal Model:
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MRL/lpr mice.
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Dosage:
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1 mg/kg.
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Administration:
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Subcutaneous injection daily from 8 to 14 weeks of age.
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Result:
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Significantly improved endothelium-dependent vasorelaxation and showed a strong trend towards downregulation of IRGs.
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CS-2826
上下游产品信息
上游原料
下游产品
1802637-39-3, CS-2826 相关搜索:
- (S)-N-(1-(1H-苯并[D]咪唑-2-基)-4-(2-氯乙酰亚胺基)丁基)-[1,1'-联苯基]-4-甲酰胺
- 化合物BB-CL-AMIDINE
- (S)-N-(1-(1H-苯并[D]咪唑-2-基)-4-(2-氯乙酰亚胺基)丁基)-[1,1'-联苯基]-4-甲酰胺
- 1802637-39-3
- (S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide
- Peptidylarginine Deiminase,Inhibitor,BBClAmidine,BB Cl Amidine,Protein Arginine Deiminase,inhibit
- [1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-
- N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-biphenylcarboxamide
- CS-2826
- BB-Cl-Amidine