BB-Cl-Amidine
- CAS No.
- 1802637-39-3
- Chemical Name:
- BB-Cl-Amidine
- Synonyms
- CS-2826;BB-Cl-Amidine;N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-biphenylcarboxamide;(S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide;Peptidylarginine Deiminase,Inhibitor,BBClAmidine,BB Cl Amidine,Protein Arginine Deiminase,inhibit;N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-4-(2-chloroethanimidamido)butyl]-[1,1'-biphenyl]-4-carboxamide;[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-
- CBNumber:
- CB63152560
- Molecular Formula:
- C26H26ClN5O
- Molecular Weight:
- 459.971
- MDL Number:
- MFCD31746879
- MOL File:
- 1802637-39-3.mol
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| solubility |
DMSO:76.33(Max Conc. mg/mL);165.94(Max Conc. mM) DMF:20.0(Max Conc. mg/mL);43.48(Max Conc. mM) Water:70.0(Max Conc. mg/mL);152.18(Max Conc. mM) Ethanol:54.5(Max Conc. mg/mL);118.48(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.09(Max Conc. mM) |
| form | A crystalline solid |
| color | white to beige |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
BB-Cl-Amidine price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17079 | BB-Cl-Amidine ≥95% | 1802637-39-3 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 17079 | BB-Cl-Amidine ≥95% | 1802637-39-3 | 10mg | $302 | 2024-03-01 | Buy |
| Cayman Chemical | 17079 | BB-Cl-Amidine ≥95% | 1802637-39-3 | 500μg | $99 | 2021-12-16 | Buy |
| Cayman Chemical | 17079 | BB-Cl-Amidine ≥95% | 1802637-39-3 | 5mg | $169 | 2024-03-01 | Buy |
| AK Scientific | 6591EJ | BB-Cl-Amidine | 1802637-39-3 | 1mg | $313 | 2021-12-16 | Buy |
BB-Cl-Amidine Chemical Properties,Uses,Production
Description
BB-Cl-Amidine is a modified version of Cl-amidine that retains the functional components but possesses a C-terminal benzimidazole group designed to limit proteolysis of the C-terminal amide. BB-Cl-Amidine irreversibly inactivates all four PAD subtypes (kinact/KI = 16,100, 4,100, 6,800, and 13,300 M-1min-1 for PAD1-4, respectively) by covalently modifying an active site cysteine that is important for its catalytic activity. The cellular potency of BB-Cl-amidine against PAD4 is increased 20-fold over the parent compound (EC50 = 8.8 μM versus >200 μM for Cl-amidine). BB-Cl-Amidine also has a significantly longer in vivo half-life than Cl-amidine (1.75 h versus ~15 min, respectively). Both compounds inhibit the formation of neutrophil extracellular traps without altering H2O2 production by neutrophils. BB-Cl-Amidine is effective in vivo, improving endothelial function while downregulating the expression of type I interferon-regulated genes in MRL/lpr mice.
Uses
BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor.
in vivo
Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely[1].
| Animal Model: | MRL/lpr mice[1]. |
| Dosage: | 1 mg/kg. |
| Administration: | Subcutaneous injection daily from 8 to 14 weeks of age. |
| Result: | Significantly improved endothelium-dependent vasorelaxation and showed a strong trend towards downregulation of IRGs. |
References
[1] Knight JS, et al. Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Ann Rheum Dis. 2015 Dec;74(12):2199-206. DOI:10.1136/annrheumdis-2014-205365
BB-Cl-Amidine Preparation Products And Raw materials
Raw materials
Preparation Products
BB-Cl-Amidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Anyinuo Biomedical Technology Co., Ltd. | 021-34625901 | 420970979@qq.com | China | 5843 | 58 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 18001021521; | sales@mreda.com.cn | China | 10788 | 58 |