1334294-76-6
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- CAS号:
- 1334294-76-6
- 英文名:
- GSK682753A
- 英文别名:
- GSK682753A;GSK-682753A,GSK682753A;EBI2 inhibitor GS682753A;(E)-8-(3-(4-Chlorophenyl)acryloyl)-3-(3,4-dichlorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one;1-Oxa-3,8-diazaspiro[4.5]decan-2-one, 8-[(2E)-3-(4-chlorophenyl)-1-oxo-2-propen-1-yl]-3-[(3,4-dichlorophenyl)methyl]-
- 中文名:
- 1334294-76-6
- 中文别名:
- 化合物 T11498
- CBNumber:
- CB63167614
- 分子式:
- C23H21Cl3N2O3
- 分子量:
- 479.78
- MOL File:
- 1334294-76-6.mol
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1334294-76-6化学性质
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沸点:
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731.8±60.0 °C(Predicted)
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密度:
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1.44±0.1 g/cm3(Predicted)
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储存条件:
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4°C, protect from light
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溶解度:
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DMSO : ≥ 27 mg/mL (56.28 mM)
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形态:
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Solid
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酸度系数(pKa):
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-0.50±0.20(Predicted)
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颜色:
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White to light yellow
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1334294-76-6性质、用途与生产工艺
GSK682753A是EB病毒诱导受体2 (EBI2) 的反向激动剂, IC50值为 53.6 nM。
GSK682753 is a selective and highly potent inverse agonist for murine as well as human EBI2 with inhibition of G protein-dependent signals as well as signals that are probably G protein-independent. In cAMP-response element-binding protein-based reporter and guanosine5'-3-O-(thio)-triphosphate (GTPγS) binding assays, the potency of this compound is 2.6-53.6 nM, and its inhibitory efficacy is 75%. GSK682753A dose-dependently inhibits EBI2 with an IC
50
of 53.6 nM. GSK682753A inhibits ERK phosphorylation, GTPγS binding, and cAMP-response element-binding protein activation with similar potency.
1334294-76-6
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-101192 | GSK682753A | | 1 mg | 636元 |
2024/04/30 | HY-101192 | 1334294-76-6 GSK682753A | 1334294-76-6 | 10mM * 1mLin DMSO | 1355元 |
1334294-76-6, 1334294-76-6 相关搜索:
- 化合物 T11498
- 1334294-76-6
- (E)-8-(3-(4-Chlorophenyl)acryloyl)-3-(3,4-dichlorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
- GSK-682753A,GSK682753A
- 1-Oxa-3,8-diazaspiro[4.5]decan-2-one, 8-[(2E)-3-(4-chlorophenyl)-1-oxo-2-propen-1-yl]-3-[(3,4-dichlorophenyl)methyl]-
- EBI2 inhibitor GS682753A
- GSK682753A