1334294-76-6
| 中文名称 | 1334294-76-6 |
|---|---|
| 中文同义词 | 化合物 T11498 |
| 英文名称 | GSK682753A |
| 英文同义词 | GSK682753A;EBI2 inhibitor GS682753A;1-Oxa-3,8-diazaspiro[4.5]decan-2-one, 8-[(2E)-3-(4-chlorophenyl)-1-oxo-2-propen-1-yl]-3-[(3,4-dichlorophenyl)methyl]-;GSK-682753A,GSK682753A;(E)-8-(3-(4-Chlorophenyl)acryloyl)-3-(3,4-dichlorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one |
| CAS号 | 1334294-76-6 |
| 分子式 | C23H21Cl3N2O3 |
| 分子量 | 479.78 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1334294-76-6.mol |
| 结构式 |  |
1334294-76-6 性质
| 沸点 | 731.8±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.44±0.1 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light |
| 溶解度 | 二甲基亚砜：≥27mg/mL（56.28mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | -0.50±0.20(Predicted) |
| 颜色 | 白色至浅黄色 |
GSK682753A是EB病毒诱导受体2 (EBI2) 的反向激动剂, IC50值为 53.6 nM。
IC50: 53.6 nM (EBI2)
GSK682753 is a selective and highly potent inverse agonist for murine as well as human EBI2 with inhibition of G protein-dependent signals as well as signals that are probably G protein-independent. In cAMP-response element-binding protein-based reporter and guanosine5'-3-O-(thio)-triphosphate (GTPγS) binding assays, the potency of this compound is 2.6-53.6 nM, and its inhibitory efficacy is 75%. GSK682753A dose-dependently inhibits EBI2 with an IC 50 of 53.6 nM. GSK682753A inhibits ERK phosphorylation, GTPγS binding, and cAMP-response element-binding protein activation with similar potency.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-101192 | GSK682753A | 1 mg | 636元 | |
| 2024/04/30 | HY-101192 | 1334294-76-6 GSK682753A | 1334294-76-6 | 10mM * 1mLin DMSO | 1355元 |