952849-76-2
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- CAS号:
- 952849-76-2
- 英文名:
- KKL-10
- 英文别名:
- KKL-10;KKL-10;KKL 10;KKL10;KKL10,Bacterial,Inhibitor,inhibit,KKL-10;5-bromo-N-(5-(p-tolyl)-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide;5-bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thiophene-2-carboxamide;2-Thiophenecarboxamide, 5-bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]-
- 中文名:
- 952849-76-2
- 中文别名:
- 化合物KKL10;5-溴-N-(5-(对甲苯基)-1,3,4-恶二唑-2-基)噻吩-2-甲酰胺
- CBNumber:
- CB63309537
- 分子式:
- C14H10BrN3O2S
- 分子量:
- 364.22
- MOL File:
- 952849-76-2.mol
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952849-76-2化学性质
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密度:
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1.620±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:2.89(Max Conc. mg/mL);7.93(Max Conc. mM)
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酸度系数(pKa):
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10.04±0.70(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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952849-76-2性质、用途与生产工艺
KKL-10 是一种 ribosome rescue 的抑制剂，对细菌具有优异的广谱抗菌活性。
| Target | Value |
ribosome rescue
()
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The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of
F. tularensis
. The minimum inhibitory concentration (MIC) against
F. tularensis
strain LVS and Schu S4 are 0.12 and 0.48 μg/mL, respectively. KKL-10 arrests intracellular growth of
F. tularensis
during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 μg/mL. The combination of IFN-γ stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of
F. tularensis
inside eukaryotic cells and show no toxicity to HepG2 cells.
952849-76-2
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-101865 | 952849-76-2
KKL-10 | 952849-76-2 | 5mg | 1300元 |
| 2024/08/19 | HY-101865 | 952849-76-2
KKL-10 | 952849-76-2 | 10mg | 2080元 |
952849-76-2, 952849-76-2 相关搜索:
- 药靶配体
- 5-溴-N-(5-(对甲苯基)-1,3,4-恶二唑-2-基)噻吩-2-甲酰胺
- 化合物KKL10
- 952849-76-2
- 2-Thiophenecarboxamide, 5-bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]-
- KKL10,Bacterial,Inhibitor,inhibit,KKL-10
- 5-bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thiophene-2-carboxamide
- KKL-10;KKL 10;KKL10
- 5-bromo-N-(5-(p-tolyl)-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide
- KKL-10