化合物KKL10
| 中文名称 | 化合物KKL10 |
|---|---|
| 中文同义词 | 化合物KKL10;5-溴-N-(5-(对甲苯基)-1,3,4-恶二唑-2-基)噻吩-2-甲酰胺 |
| 英文名称 | KKL-10 |
| 英文同义词 | KKL-10;5-bromo-N-(5-(p-tolyl)-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide;KKL-10;KKL 10;KKL10;5-bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thiophene-2-carboxamide;KKL10,Bacterial,Inhibitor,inhibit,KKL-10;2-Thiophenecarboxamide, 5-bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]- |
| CAS号 | 952849-76-2 |
| 分子式 | C14H10BrN3O2S |
| 分子量 | 364.22 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 952849-76-2.mol |
| 结构式 |  |
化合物KKL10 性质
| 密度 | 1.620±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：2.89（最大浓度 mg/mL）；7.93（最大浓度 mM） |
| 酸度系数(pKa) | 10.04±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| Target | Value |
|
ribosome rescue
() |
The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis . The minimum inhibitory concentration (MIC) against F. tularensis strain LVS and Schu S4 are 0.12 and 0.48 μg/mL, respectively. KKL-10 arrests intracellular growth of F. tularensis during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 μg/mL. The combination of IFN-γ stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-101865 | 952849-76-2 KKL-10 | 952849-76-2 | 5mg | 1300元 |
| 2024/11/08 | S0147 | 952849-76-2 KKL-10 | 952849-76-2 | 5mg | 1576.46元 |