(S)-(-)-BAY-K-8644
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- CAS号:
- 98625-26-4
- 英文名:
- S(-)-BAY K 8644
- 英文别名:
- R-5417;BAY-r-5417;S(-)-BAY K 8644;(-)-(s)-bayk8644;Bay-K-8644 ((S)-(-)-);S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO;Bay-K-8644 (S)-(-)-[(S)-(-)-Bay-K-8644;Ca channels,Inhibitor,(S) ( ) Bay K 8644,inhibit,(S)()BayK8644,Calcium Channel,Ca2+ channels;methyl (-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]pyridine-3-carboxylate;Methyl (S)-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylate
- 中文名:
- (S)-(-)-BAY-K-8644
- 中文别名:
- 化合物(S)-(-)-BAY K 8644;(S)-(-)-BAY K 8644,CAV1.X激活剂;(S)-2,6-二甲基-5-硝基-4-(2-三氟甲基)苯基)-1,4-二氢吡啶-3-甲酸甲酯
- CBNumber:
- CB6448884
- 分子式:
- C16H15F3N2O4
- 分子量:
- 356.3
- MOL File:
- 98625-26-4.mol
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(S)-(-)-BAY-K-8644化学性质
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储存条件:
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2-8°C
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溶解度:
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H2O: slightly soluble
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形态:
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solid
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颜色:
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yellow
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(S)-(-)-BAY-K-8644性质、用途与生产工艺
(S)-(-)-Bay-K-8644 是 L 型钙离子通道激动剂。(S)-(-)-Bay-K-8644 激活 Ba2+电流 (IBa)，EC50 为 32 nM。
(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca
2+
channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on I
Ba
in gastric myocytes of the guinea pig antrum. The Ca
2+
channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca
2+
channels. The interactions of two Ca
2+
channel activators (S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca
2+
channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC
50
=14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca
2+
currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176.
(S)-(-)-BAY-K-8644
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15124 | (S)-(-)-Bay-K-8644 | | 1 mg | 678元 |
| 2024/04/30 | HY-15124 | (S)-(-)-BAY-K-8644
(S)-(-)-Bay-K-8644 | 98625-26-4 | 5mg | 1350元 |
98625-26-4, (S)-(-)-BAY-K-8644 相关搜索:
- Calcium channel
- 合成有机化合物配体
- Voltage-gated Ion Channels
- Ion Channels
- Inhibitors and Activators
- Calcium Channel Modulators
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- C16H15F3N2O4
- (S)-(-)-BAY K 8644,CAV1.X激活剂
- 化合物(S)-(-)-BAY K 8644
- (S)-2,6-二甲基-5-硝基-4-(2-三氟甲基)苯基)-1,4-二氢吡啶-3-甲酸甲酯
- 98625-26-4
- (-)-(s)-bayk8644
- Methyl (S)-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylate
- Ca channels,Inhibitor,(S) ( ) Bay K 8644,inhibit,(S)()BayK8644,Calcium Channel,Ca2+ channels
- Bay-K-8644 (S)-(-)-[(S)-(-)-Bay-K-8644
- 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-, methyl ester, (4S)-
- methyl (-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]pyridine-3-carboxylate
- Bay-K-8644 ((S)-(-)-)
- R-5417
- BAY-r-5417
- [4S,(-)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester
- s-(-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
- (4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester
- S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO
- (4S)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
- S(-)-BAY K 8644