(S)-(-)-BAY-K-8644

(S)-(-)-BAY-K-8644

中文名称(S)-(-)-BAY-K-8644
中文同义词(S)-2,6-二甲基-5-硝基-4-(2-三氟甲基)苯基)-1,4-二氢吡啶-3-甲酸甲酯;化合物(S)-(-)-BAY K 8644;(S)-(-)-BAY K 8644,CAV1.X激活剂
英文名称S(-)-BAY K 8644
英文同义词S(-)-BAY K 8644;(4S)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO;(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester;s-(-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester;[4S,(-)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester;BAY-r-5417;R-5417
CAS号98625-26-4
分子式C16H15F3N2O4
分子量356.3
EINECS号
相关类别Calcium channel
Mol文件98625-26-4.mol
结构式(S)-(-)-BAY-K-8644 结构式

(S)-(-)-BAY-K-8644 性质

储存条件2-8°C
溶解度H2O:微溶
形态固体
颜色粘黄色

(S)-(-)-BAY-K-8644 用途与合成方法

(S)-(-)-Bay-K-8644 是 L 型钙离子通道激动剂。(S)-(-)-Bay-K-8644 激活 Ba2+电流 (IBa),EC50 为 32 nM。

EC50: 32 nM (I Ba )

(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca 2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on I Ba in gastric myocytes of the guinea pig antrum. The Ca 2+ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca 2+ channels. The interactions of two Ca 2+ channel activators (S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca 2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC 50 =14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca 2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176.

安全信息

危险品标志Xi
危险类别码36/38
安全说明26-36
WGK Germany3
海关编码2933399990

MSDS信息

提供商 语言
英文
更新日期产品编号产品名称CAS号包装价格
2024/11/08HY-15124(S)-(-)-Bay-K-86441 mg678元
2024/11/08HY-15124(S)-(-)-BAY-K-8644
(S)-(-)-Bay-K-8644
98625-26-45mg1350元

(S)-(-)-BAY-K-8644 上下游产品信息

"(S)-(-)-BAY-K-8644"相关产品信息
2-甲-1-硝丙烷 菲尼布特 3-[2-(三氟甲基)苯基]丙酸
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