葫芦素 I
|
|
|
- CAS号:
- 2222-07-3
- 英文名:
- CUCURBITACIN I
- 英文别名:
- JSI-124;Ibamarin;ELATERIN B;NSC 521777;ELATERICIN B;CUCURBITACIN I;5-tetrahydroxy-;cucurbitacine(i);Cucurbitacin I-RM;CUCURBITACIN I(SH)
- 中文名:
- 葫芦素 I
- 中文别名:
- 葫芦素;葫芦素 I;葫芦素I(甄准不供应);葫芦素I 117793;CUCURBITACIN I 葫芦素I
- CBNumber:
- CB6480840
- 分子式:
- C30H42O7
- 分子量:
- 514.65
- MOL File:
- 2222-07-3.mol
|
|
|
葫芦素 I化学性质
-
熔点:
-
148-150°C
-
|
-
沸点:
-
698.3±55.0 °C(Predicted)
-
|
-
密度:
-
1.26±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
-20°C
-
|
-
溶解度:
-
≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic
-
|
-
酸度系数(pKa):
-
8.51±0.70(Predicted)
-
|
-
形态:
-
solid
-
|
-
颜色:
-
white to off-white
-
|
-
LogP:
-
2.330 (est)
-
|
葫芦素 I性质、用途与生产工艺
Cucurbitacin I 是 JAK2/STAT3 的天然选择性抑制剂，并具有有效的抗肿瘤活性。
Exposure of the COLO205 cells to Cucurbitacin I significantly decreases cell viability. The anticancer activity of Cucurbitacin I is accomplished by downregulating p-STAT3 and MMP-9 expression. PE-induced cell enlargement and upregulation of ANF and β-MHC are significantly suppressed by pretreatment of the cardiomyocytes with Cucurbitacin I. Notably, Cucurbitacin I also impaires connective tissue growth factor (CTGF) and MAPK signaling, pro-hypertrophic factors, as well as TGF-β/Smad signaling, the important contributing factors to fibrosis. Incubation of the Seax cell line with the Jak/Stat3 inhibitor Cucurbitacin I result in a time- and concentration-dependent decrease of P-Stat3 and Stat3. In freshly isolated Sz cells (n=3), Cucurbitacin I induces a concentration-dependent decrease in Stat3 expression whereas P-Stat3 is undetectable. Finally, incubation of freshly isolated Sz cells (n=4) with 30 μM Cucurbitacin I for 6 hours induces apoptosis in the large majority (73-91%) of tumor cells.
No major side effects are noted throughout the study. It is shown that average tumor volumes at the end of the study are as follows: control, 616 mm
3
(±130); CQ, 580 mm
3
(±107); Cucurbitacin I, 346mm
3
(±79); and combination, 220mm
3
(±62). The differences in tumor volume between the Cucurbitacin I and control, combination and control, and combination and Cucurbitacin I arms are significant. Furthermore, combination-treated tumors exhibit a significantly lower average tumor weight at study termination than the control. Moreover, there was no effect on the body weights of mice.
葫芦素 I
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-N1405 | 葫芦素 I
Cucurbitacin I | 2222-07-3 | 1mg | 1480元 |
| 2024/11/08 | HY-N1405 | 葫芦素 I
Cucurbitacin I | 2222-07-3 | 5mg | 3780元 |
葫芦素 I
生产厂家
全球有 117家供应商
葫芦素 I国内生产厂家
2222-07-3, 葫芦素 I 相关搜索:
- Tri-Terpenoids
- API
- Herb extract
- Inhibitor
- 抑制剂
- 化合物
- 小分子
- 对照品
- 中药对照品
- 植物提取物
- 2222-7-3
- 葫芦素I 117793
- CUCURBITACIN I 葫芦素I
- 葫芦素I(甄准不供应)
- 葫芦素
- 葫芦素 I
- 2222-07-3
- Cucurbitacin I(AS)
- Cucurbitacin I-RM
- 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9β,10α,16α,23E)-
- Cucurbitacin I (Elatericin B
- cucurbitacine(i)
- 5-tetrahydroxy-
- 2,16alpha,20,25-tetrahydroxy-9beta-methyl-10alpha-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
- JSI-124
- 19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,9-methyl-2,16,20,2
- 1,2-dehydroelatericina
- CUCURBITACIN I
- calebassine/cucurbitacin
- Cucurbitacin I (JSI-124)
- NSC 521777
- 2,16α,20,25-tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione
- (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
- CUCURBITACIN I hplc
- CUCURBITACIN I(SH)
- 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9b,10a,16a,23E)-
- 2,16α,20,25-tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
- 2,16a,20,25-Tetrahydroxy-9b-methyl-10a-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
- Ibamarin
- (9β,10α,23E)-2,16α,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
- Elatericin B, JSI-124, NSC 521777, 2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione
- Cucurbitacin I hydrate
- CUCURBITACIN I WITH HPLC
- ELATERIN B
- ELATERICIN B