FEN1 Inhibitor C2
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- CAS号:
- 1995893-58-7
- 英文名:
- FEN1 Inhibitor C2
- 英文别名:
- FEN1-IN-4;FEN1 Inhibitor C2;FEN1-IN-4, 10 mM in DMSO;1-(Cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione;2,4(1H,3H)-Quinazolinedione, 1-(cyclopropylmethyl)-3-hydroxy-;flap,colorectal,Inhibitor,endonuclease,FEN1IN4,cells,colon,cancer,inhibit,FEN-1-IN-4,glioblastoma,FEN1 IN 4,human,hFEN1
- 中文名:
- FEN1 Inhibitor C2
- 中文别名:
- 化合物FEN1 INHIBITOR C2;1-(环丙基甲基)-3-羟基喹唑啉-2,4(1H,3H)-二酮;化合物FEN1 INHIBITOR C2,10 MM DMSO 溶液
- CBNumber:
- CB65864131
- 分子式:
- C12H12N2O3
- 分子量:
- 232.24
- MOL File:
- 1995893-58-7.mol
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FEN1 Inhibitor C2化学性质
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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DMSO: 125 mg/mL (538.24 mM)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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FEN1 Inhibitor C2性质、用途与生产工艺
FEN1-IN-4 (Compound 2) 是一种人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in
Cdc4
and
Mre11a
, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.
FEN1 Inhibitor C2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/02/08 | HY-136485 | FEN1-IN-4 | 1995893-58-7 | 1 mg | 419元 |
| 2025/02/08 | HY-136485 | FEN1 Inhibitor C2
FEN1-IN-4 | 1995893-58-7 | 5mg | 1000元 |
1995893-58-7, FEN1 Inhibitor C2 相关搜索:
- 抑制剂
- 药靶配体
- 化合物FEN1 INHIBITOR C2,10 MM DMSO 溶液
- 化合物FEN1 INHIBITOR C2
- 1-(环丙基甲基)-3-羟基喹唑啉-2,4(1H,3H)-二酮
- 1995893-58-7
- FEN1-IN-4, 10 mM in DMSO
- flap,colorectal,Inhibitor,endonuclease,FEN1IN4,cells,colon,cancer,inhibit,FEN-1-IN-4,glioblastoma,FEN1 IN 4,human,hFEN1
- 1-(Cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione
- 2,4(1H,3H)-Quinazolinedione, 1-(cyclopropylmethyl)-3-hydroxy-
- FEN1-IN-4
- FEN1 Inhibitor C2