FEN1 Inhibitor C2
中文名称 | FEN1 Inhibitor C2 |
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中文同义词 | 1-(环丙基甲基)-3-羟基喹唑啉-2,4(1H,3H)-二酮;化合物FEN1 INHIBITOR C2 |
英文名称 | FEN1 Inhibitor C2 |
英文同义词 | FEN1 Inhibitor C2;FEN1-IN-4;2,4(1H,3H)-Quinazolinedione, 1-(cyclopropylmethyl)-3-hydroxy-;1-(Cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione;flap,colorectal,Inhibitor,endonuclease,FEN1IN4,cells,colon,cancer,inhibit,FEN-1-IN-4,glioblastoma,FEN1 IN 4,human,hFEN1 |
CAS号 | 1995893-58-7 |
分子式 | C12H12N2O3 |
分子量 | 232.24 |
EINECS号 | |
相关类别 | |
Mol文件 | 1995893-58-7.mol |
结构式 |
FEN1 Inhibitor C2 性质
储存条件 | Inert atmosphere,Store in freezer, under -20°C |
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溶解度 | 二甲基亚砜:125 mg/mL(538.24 mM) |
形态 | 固体 |
颜色 | 浅黄至黄色 |
hFEN1
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a , both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-136485 | FEN1-IN-4 | 1 mg | 419元 | |
2024/04/30 | HY-136485 | FEN1 Inhibitor C2 FEN1-IN-4 | 1995893-58-7 | 5mg | 1000元 |