8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
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- CAS号:
- 51116-01-9
- 英文名:
- 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
- 英文别名:
- BR-CGMP, NA;8-BR-CGMP NA;8-BROMO-CGMP NA;Einecs 256-993-8;8-BROMO-CGMP SODIUM;8-BR-CGMP SODIUM SALT;(115974-70-4) 8-AET-cGMP;8-BROMO-CGMP, SODIUM SALT;8-bromo-Cyclic GMP (sodium salt);8 Bromo cGMP sodium,8BromocGMP sodium
- 中文名:
- 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
- 中文别名:
- 8-溴-CGMP钠;化合物 T14064;8-溴鸟嘌呤3',5'-环一磷酸 钠盐;8-溴代鸟苷-3',5'-环状单磷酸酯钠盐;8-BR-CGMP (8-BROMO-CGMP),PKG活化剂
- CBNumber:
- CB6687726
- 分子式:
- C10H12BrN5NaO7P
- 分子量:
- 448.1
- MOL File:
- 51116-01-9.mol
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8-溴代鸟苷-3',5'-环状单磷酸酯钠盐化学性质
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储存条件:
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-20°C
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溶解度:
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H2O: 100 mg/mL
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形态:
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powder
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颜色:
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White to off-white
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水溶解性:
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Soluble to 100 mM in water
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8-溴代鸟苷-3',5'-环状单磷酸酯钠盐性质、用途与生产工艺
8-Bromo-cGMP sodium 是 cGMP 的膜渗透性类似物，是一种 PKG 激活剂。8-Bromo-cGMP sodium 可显着抑制 Ca2+ 宏观电流并损害高 K+ 刺激的胰岛素释放。8-Bromo-cGMP sodium 具有镇痛和血管舒张作用。
8-Bromo-cGMP sodium (1-100 μM; 8 h) increases resistance of LLC-PK1 cells to CsA toxicity concentration-dependently.
8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion.
Cell Viability Assay
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Cell Line:
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LLC-PK1 cells (ATCC CL 101)
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Concentration:
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1-100 μM
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Incubation Time:
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8 hours
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Result:
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Increased resistance of LLC-PK1 cells to Cyclosporin A (CsA) toxicity concentration-dependently and augmented cell viability by up to 65%.
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Western Blot Analysis
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Cell Line:
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LLC-PK1 cells (ATCC CL 101)
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Concentration:
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1-100 μM
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Incubation Time:
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16 hours
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Result:
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Induced the synthesis of HO-1 protein in a concentration-dependent fashion.
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8-Bromo-cGMP sodium (0.3, 1, 3.0 nmol; intrathecal administration; 10 min before test) dose-dependently and significantly increases the tail-flick latency in Vincristine-treated mice to the level observed in vehicle-treated naive mice (male ICR mice, 4weeks of age and weighing 20 g). Vincristine (0.05 mg/kg 1 day after the pre-drug tail-flick latency, and then 0.125 mg/kg twice a week for 6 weeks) can induce painful neuropathy in mice.
8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in eNOS-Tg mice and WT littermates in C57BL/6 background (19-35 g).
8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/02/08 | HY-101379A | 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
8-Bromo-cGMP sodium | 51116-01-9 | 5mg | 700元 |
| 2025/02/08 | HY-101379A | 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
8-Bromo-cGMP sodium | 51116-01-9 | 10mM * 1mLin Water | 770元 |
8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
生产厂家
51116-01-9, 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐 相关搜索:
- Serine/Threonine Kinase Activators
- Protein Kinase G (PKG)
- G Proteins and Cyclic Nucleotides
- Cyclic Nucleotides and AnalogsSerine/Threonine Kinase Biology
- Cyclic Nucleotide Metabolism
- Cyclic Nucleotide related
- 抑制剂
- Nucleosides, Nucleotides, Oligonucleotides
- Nucleoside Analogs
- Cyclic Nucleotides and Analogs
- Cyclic Nucleotide Metabolism
- G Proteins and Cyclic Nucleotides
- BioChemical
- Biochemicals and Reagents
- Cell Signaling and Neuroscience
- Cell Biology
- C10H10BrN5O7PNa
- C10H10BrN5NaO7P
- 8-BR-CGMP (8-BROMO-CGMP),PKG活化剂
- 8-溴-CGMP钠
- 8-溴鸟嘌呤3',5'-环一磷酸 钠盐
- 化合物 T14064
- 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
- 51116-01-9
- 8-Br-cGMP (8-Bromo-cGMP), PKG activator
- 8 Bromo cGMP sodium,8BromocGMP sodium
- 8-Bromoguanosine3′,5′-cyclicmonophosphatesodiumsal
- Guanosine 3,5-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 51116-01-9 - Calbiochem
- 8-bromo-Cyclic GMP (sodium salt)
- (115974-70-4) 8-AET-cGMP
- Einecs 256-993-8
- 8-BROMOGUANOSINE-3,5-CYCLICMONOPHOSPHATESODIUMSALT,ULTRAPURE
- 8-BROMOGUANOSINE-3',5'-CYCLOPHOSPHATE SODIUM SALT
- 8-BROMOGUANOSINE-3',5'-CYCLOPHOSPHATE SODIUM
- 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
- 8-BROMOGUANOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
- 8-BROMOGUANOSINE CYCLIC 3',5'-MONOPHOSPHATE SODIUM SALT
- 8-BROMO-CGMP, SODIUM SALT
- 8-BROMO-CGMP SODIUM
- 8-BROMO-CGMP NA
- 8-BR-CGMP SODIUM SALT
- 8-BR-CGMP NA
- BR-CGMP, NA
- GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-BROMO-, SODIUM SALT
- 8-BROMO-CGMP SODIUM SALT 8-BROMOGUANOSIN E-3',5
- 8-BROMOGUANOSINE 3':5'-CYCLICMONOPHOSPHA TE SODIUM
- Guanosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate), monosodium salt
- 8-Bromoguanosine-3,5-cyclomonophosphate sodium salt
- 8-bromoguanosine 3:5-cyclic*monophosphate sodiu
- 8-bromoguanosine-3’,5’-cyclicmonophosphate(8-br-cgmp),sodiumsalt,