菝葜
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- CAS号:
- 126-18-1
- 英文名:
- SMILAGENIN
- 英文别名:
- Cogane;Nsc93747;PYM50028;AI3-44895;PYM 50028;SMILAGENIN;ESMILAGENIN;ISOSARSAPOGENIN;Smilax china L;ISOSARSAPOGENINE
- 中文名:
- 菝葜
- 中文别名:
- 菝葜;菝葜配質;菝葜配基;异菝葜皂苷;异菝葜皂甙;异知母皂苷元;化合物 T4954L;化合物 SMILAGENIN;PYM50028|||COGANE|||AI3-44895|||PYM 50028
- CBNumber:
- CB6750868
- 分子式:
- C27H44O3
- 分子量:
- 416.64
- MOL File:
- 126-18-1.mol
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菝葜化学性质
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熔点:
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~185 °C
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比旋光度:
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D25 -69° (c = 0.5 in chloroform)
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沸点:
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474.91°C (rough estimate)
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密度:
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1.0362 (rough estimate)
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折射率:
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1.4700 (estimate)
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储存条件:
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Store at -20°C
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溶解度:
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Ethanol: ≥ 10 mg/mL (24.00 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
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酸度系数(pKa):
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15.14±0.70(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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菝葜性质、用途与生产工艺
Smilagenin (SMI) 是一种脂溶性小分子甾体皂苷元，来自知母 Rhizoma anemarrhenae 和天竺葵 Radix asparagi，广泛用于慢性神经退行性疾病的研究。Smilagenin (SMI) 通过增加毒蕈碱受体亚型 1 (M1)-受体的的密度来改善老年大鼠的记忆。
Smilagenin (SMI) 通过刺激脑源性神经营养因子的基因表达减弱 Aβ (25-35) 诱导的神经变性，可用于 AD 的研究。
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Human Endogenous Metabolite
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Smilagenin (10 μM; 24 hours) increases SH-SY5Y cell survival compared with Aβ(25-35) intoxicated cells.
Smilagenin (10 μM; 24 hours) increases neurotrophic factor (GDNF) and neurotrophic factor (BDNF) mRNA level by promoting CREB phosphorylation in 1-methyl-4-phenylpyridimium (MPP
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Cell Viability Assay
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Cell Line:
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SH-SY5Y cells
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Concentration:
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10 μM
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Incubation Time:
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24 hours
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Result:
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Elevated the SH-SY5Y cell viability.
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RT-PCR
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Cell Line:
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SH-SY5Y cells
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Concentration:
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10 μM
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Incubation Time:
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24 hours
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Result:
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Increased GDNF and BDNF transcription.
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Smilagenin (intragastric administration; 10 or 26 mg/kg, once daily; 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model.
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Animal Model:
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MPTP/probenecid-induced mouse model
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Dosage:
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10 or 26 mg/kg
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Administration:
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Intragastric administration; 10 or 26 mg/kg; once daily; 60 days
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Result:
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Ameliorated locomotor ability of MPTP/probenecid-lesioned mice.
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菝葜
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-106353 | 菝葜
Smilagenin | 126-18-1 | 5mg | 800元 |
| 2024/11/08 | HY-106353 | 菝葜
Smilagenin | 126-18-1 | 10mg | 1200元 |
菝葜
生产厂家
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菝葜国内生产厂家
126-18-1, 菝葜 相关搜索:
- Steroids
- 抑制剂
- 比列产品
- 中草药成分
- Analytical Standards
- Alphabetic
- Analytical Chromatography Product Catalog
- SA - SM
- 化合物 SMILAGENIN
- PYM50028|||COGANE|||AI3-44895|||PYM 50028
- 异菝葜皂苷
- 化合物 T4954L
- 异知母皂苷元
- 菝葜
- 菝葜配基
- 异菝葜皂甙
- 菝葜配質
- 126-18-1
- 5β, 20α, 22α, 25D-SPIROSTAN-3β-OL
- PYM50028
- PYM 50028
- Cogane
- AI3-44895
- SMILAGENIN USP/EP/BP
- (25R)-5β-spirostan-3β-ol
- Spirostan-3-ol, (3β,5β,25R)-
- Smilax china L
- 16,22:22,26-BIS(EPOXY)CHOLESTAN-3BETA-OL
- (25R)-SPIROSTAN-3BETA-OL
- 25R,5BETA-SPIROSTAN-3BETA-OL
- 5-BETA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL
- 5BETA,20ALPHA,22ALPHA,25D-SPIRANOSTAN-3BETA-OL
- ESMILAGENIN
- ISOSARSASAPOGENIN
- ISOSARSAPOGENINE
- ISOSARSAPOGENIN
- 16,22:22,26-Bis(epoxy)cholestan-3β-ol
- (3β,5β,25R)-Spirostan-3-ol
- Spirostan-3-ol, (3.beta.,5.beta.,25R)-
- Nsc93747
- 5.beta.-Spirostan-3.beta.-ol, (25R)-
- (25R)-Spirostan-3β-ol, 16,22:22,26-Bis(epoxy)cholestan-3β-ol
- (25r)-spirostan-3β-ol
- SMILAGENIN