SEC
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|
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- CAS号:
- 1802997-81-4
- 英文名:
- 1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester
- 英文别名:
- SEC;1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester
- 中文名:
- SEC
- 中文别名:
- 金黄色葡萄球菌肠毒素C(SEC)ELISA试剂盒
- CBNumber:
- CB68108739
- 分子式:
- C22H23ClN2O5
- 分子量:
- 430.88
- MOL File:
- 1802997-81-4.mol
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SEC化学性质
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沸点:
-
627.7±55.0 °C(Predicted)
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密度:
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1.27±0.1 g/cm3(Predicted)
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-
酸度系数(pKa):
-
13.31±0.20(Predicted)
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形态:
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Oil
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颜色:
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Light yellow to yellow
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SEC性质、用途与生产工艺
SEC 通过 AMPK/mTORC1/STAT3 信号通路诱导 ANXA7 GTPase 的激活。SEC 选择性的促进癌细胞的凋亡，诱导 ITGB4 核转位，表达高水平 ITGB4。
SEC (20 µM) inhibits the cell migration of HEK 293T RKIP
−/−
cells and PC3 prostate cancer cells.
SEC (20 µM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (
cell selectively
).
Cell Viability Assay
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Cell Line:
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HEK293T RKIP
−/−
cells.
[1]
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Concentration:
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20 µM.
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Incubation Time:
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24 h.
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Result:
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Suppressed HEK293T RKIP
−/−
cell migration while had no effect on HEK293T RKIP
+/+
cells.
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SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model.
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Animal Model:
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Luciferase-labeled PC-3M-Luc cells (2×10
6
per 50 µL sterile HBSS
−/−
) are orthotopically inoculated into the prostates of 8-week-old nude mice.
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Dosage:
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3 mg/kg/day or 18 mg/kg/day.
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Administration:
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IP daily for 3 weeks.
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Result:
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Suppressed the lymph node metastatic capacities of PC-3M-Luc cells in the nude mice model.
Decreased the mRNA level of
CCL2
,
APLN
and
IL6ST
in implanted tumors.
Did not affect the body weight of the mice.
|
SEC
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-125355 | SEC | | 1 mg | 1363元 |
| 2024/08/19 | HY-125355 | SEC | 1802997-81-4 | 5mg | 3000元 |
1802997-81-4, SEC 相关搜索:
- 金黄色葡萄球菌肠毒素C(SEC)ELISA试剂盒
- 1802997-81-4
- SEC
- 1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester