SEC
| 中文名称 | SEC |
|---|---|
| 中文同义词 | 金黄色葡萄球菌肠毒素C(SEC)ELISA试剂盒 |
| 英文名称 | 1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester |
| 英文同义词 | 1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester;SEC |
| CAS号 | 1802997-81-4 |
| 分子式 | C22H23ClN2O5 |
| 分子量 | 430.88 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1802997-81-4.mol |
| 结构式 |  |
SEC 性质
| 沸点 | 627.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 13.31±0.20(Predicted) |
| 形态 | 油状物 |
| 颜色 | 浅黄至黄色 |
SEC 通过 AMPK/mTORC1/STAT3 信号通路诱导 ANXA7 GTPase 的激活。SEC 选择性的促进癌细胞的凋亡，诱导 ITGB4 核转位，表达高水平 ITGB4。
SEC (20 µM) inhibits the cell migration of HEK 293T RKIP
−/−
cells and PC3 prostate cancer cells.
SEC (20 µM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (
cell selectively
).
Cell Viability Assay
| Cell Line: | HEK293T RKIP −/− cells. [1] |
| Concentration: | 20 µM. |
| Incubation Time: | 24 h. |
| Result: | Suppressed HEK293T RKIP −/− cell migration while had no effect on HEK293T RKIP +/+ cells. |
SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model.
| Animal Model: |
Luciferase-labeled PC-3M-Luc cells (2×10
6
per 50 µL sterile HBSS
−/−
) are orthotopically inoculated into the prostates of 8-week-old nude mice.
|
| Dosage: | 3 mg/kg/day or 18 mg/kg/day. |
| Administration: | IP daily for 3 weeks. |
| Result: |
Suppressed the lymph node metastatic capacities of PC-3M-Luc cells in the nude mice model.
Decreased the mRNA level of CCL2 , APLN and IL6ST in implanted tumors. Did not affect the body weight of the mice. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-125355 | SEC | 1802997-81-4 | 5mg | 3000元 |
| 2024/04/30 | HY-125355 | SEC | 1802997-81-4 | 10mM * 1mLin DMSO | 3300元 |