133575-27-6
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- CAS号:
- 133575-27-6
- 英文名:
- 133575-27-6
- 英文别名:
- Ara-F-NAD+
- 中文名:
- 中文别名:
- CBNumber:
- CB68871239
- 分子式:
- C21H26FN7O13P2
- 分子量:
- 665.42
- MOL File:
- 133575-27-6.mol
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133575-27-6性质、用途与生产工艺
Ara-F-NAD+ 是 NAD+ 的 arabino 类似物，是一种有效的、缓慢结合的 CD38 NADase 抑制剂，其 Ki 为 1. 69 nM.
The leucoyte surface antigen CD38 has been shown to be an ecto-enzyme with multiple catalytic activities. It is principally a NAD
+
glycohydrolase that transforms NAD
+
into ADP-ribose and nicotinamide. CD38 is also able to produce small amounts of cyclic ADP-ribose (ADP-ribosyl cyclase activity) and to hydrolyse this cyclic metabolite into ADP-ribose (cyclic ADP-ribose hydrolase activity).
133575-27-6
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