| 中文名称 | 133575-27-6 |
|---|---|
| 中文同义词 | |
| 英文名称 | 133575-27-6 |
| 英文同义词 | Ara-F-NAD+ |
| CAS号 | 133575-27-6 |
| 分子式 | C21H26FN7O13P2 |
| 分子量 | 665.42 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 133575-27-6.mol |
| 结构式 |  |
133575-27-6 性质
Ara-F-NAD+ 是 NAD+ 的 arabino 类似物，是一种有效的、缓慢结合的 CD38 NADase 抑制剂，其 Ki 为 1. 69 nM.
The leucoyte surface antigen CD38 has been shown to be an ecto-enzyme with multiple catalytic activities. It is principally a NAD + glycohydrolase that transforms NAD + into ADP-ribose and nicotinamide. CD38 is also able to produce small amounts of cyclic ADP-ribose (ADP-ribosyl cyclase activity) and to hydrolyse this cyclic metabolite into ADP-ribose (cyclic ADP-ribose hydrolase activity).