德夸菌素
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- CAS号:
- 2004-04-8
- 英文名:
- DECOYININE
- 英文别名:
- a14;U-7984;decoyinin;DECOYININE;angustmycina;antibiotica14;Decoyinine (U-7984);Decoyinine [AngustMycin A];5,6-Psicofuranosenyladenine;4',5'-didehydro-1'-C-(hydroxymethyl)-adenosine
- 中文名:
- 德夸菌素
- 中文别名:
- 狭霉素A;德夸菌素;谷维菌素德夸霉素;化合物 T15091;德夸菌素 (2004-04-8 );9-(6-脱氧-Β-D-赤式-己-5-烯-2-基呋喃糖基)-9-嘌呤-6-胺
- CBNumber:
- CB7109485
- 分子式:
- C11H13N5O4
- 分子量:
- 279.25
- MOL File:
- 2004-04-8.mol
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德夸菌素化学性质
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熔点:
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198-200℃
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沸点:
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639.8±65.0 °C(Predicted)
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密度:
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1.87±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: soluble
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形态:
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A crystalline solid
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酸度系数(pKa):
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12.90±0.60(Predicted)
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颜色:
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White to off-white
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德夸菌素性质、用途与生产工艺
Decoyinine 是 GMP 合成酶的一个选择性抑制剂。
Decoyinine is an analog of adenosine which causes a decrease in intracellular GTP levels by inhibition of GMP synthetase. Decoyinine exerts a stimulatory effect on oaamylase synthesis only in the strain in which the catabolite repression component of a-amylase regulation has been rendered inoperable by the
gra-10
mutation. The apparent stimnulation of a-amylase activity in WLN-11 by Decoyinine is not an artifactual effect exerted at the level of enzyme activity itself. It is observed that purine nucleotides, most notably GMP, exhibits a dramatic inhibitory effect on the activity of Bacillus circulans F-2 amylase and a less-pronounced inhibitory effect on
B. subtilis
aamylase. At the concentration used in the experiments (1.07 mM), Decoyinine has no effect in vitro on
B. subtilis
WLN-11 oaamylase activity. At the same concentration, GMP exerts a slight inhibitory effect on aamylase activity.
It is showed that Decoyinine (Angustmycin A) treatment hinders tumor growth in xenograft mouse model. Moreover, like GMPS activity, the effect of Decoyinine does not appear to be subtype specific as it impairs growth of xenografts from cells harboring NRASQ61R (SK-Mel-103) or BRAFV600E (SK-Mel-28) mutations.
德夸菌素
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101835 | 德夸菌素
Decoyinine | 2004-04-8 | 1mg | 900元 |
| 2024/04/30 | HY-101835 | 德夸菌素
Decoyinine | 2004-04-8 | 5mg | 3500元 |
德夸菌素
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2004-04-8, 德夸菌素 相关搜索:
- C10H11N5O4
- 谷维菌素德夸霉素
- 德夸菌素 (2004-04-8 )
- 化合物 T15091
- 狭霉素A
- 9-(6-脱氧-Β-D-赤式-己-5-烯-2-基呋喃糖基)-9-嘌呤-6-胺
- 德夸菌素
- 2004-04-8
- Adenosine, 4',5'-didehydro-1'-C-(hydroxymethyl)-
- 4',5'-didehydro-1'-C-(hydroxymethyl)-adenosine
- angustmycina
- a14
- 9-(tetrahydro-3,4-dihydroxy-2-(hydroxymethyl)-5-methylene-2-furyl)adenine
- 9-(tetrahydro-3,4-dihydroxy-2-(hydroxymethyl)-5-methylene-2-furyl)-adenin
- 9-(6-deoxy-beta-d-erythro-hex-5-enulofuranosyl)adenine
- 9-(6-deoxy-beta-d-erythro-hex-5-enulofuranosyl)-adenin
- 9-(6-deoxy-beta-d-erythro-hex-5-en-2-ulofuranosyl)-9h-purin-6-amin
- U-7984
- DECOYININE
- decoyinin
- antibiotica14
- 9H-Purin-6-amine, 9-(6-deoxy-β-D-erythro-hex-5-en-2-ulofuranosyl)-
- Decoyinine (U-7984)
- 9-(6-Deoxy-D-β-erythro-hex-5-en-2-ulofuranosyl)adenine
- 5,6-Psicofuranosenyladenine
- Decoyinine [AngustMycin A]
- (2R,3R,4S)-2-(6-azanylpurin-9-yl)-2-(hydroxymethyl)-5-methylidene-oxolane-3,4-diol
- (2R,3R,4S)-2-(6-aminopurin-9-yl)-5-methylene-2-methylol-tetrahydrofuran-3,4-diol
- (2R,3R,4S)-2-(6-aminopurin-9-yl)-2-(hydroxymethyl)-5-methylideneoxolane-3,4-diol
- 9-(6-Deoxy-β-D-erythro-5-hexeno-2-furanulonosyl)-9H-purin-6-amine