166335-18-8
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- CAS号:
- 166335-18-8
- 英文名:
- PNU 103017
- 英文别名:
- PNU 103017;PNU103017,PNU 103017;Benzenesulfonamide, 4-cyano-N-[3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3-yl)methyl]phenyl]-
- 中文名:
- 166335-18-8
- 中文别名:
- 化合物 T16555;化合物 PNU-103017
- CBNumber:
- CB71395230
- 分子式:
- C28H28N2O5S
- 分子量:
- 504.6
- MOL File:
- 166335-18-8.mol
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166335-18-8化学性质
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沸点:
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721.3±70.0 °C(Predicted)
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密度:
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1.39±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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4.50±1.00(Predicted)
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166335-18-8性质、用途与生产工艺
PNU-103017 是一种 HIV 蛋白酶抑制剂。
PNU-103017 is a selective HIV aspartyl protease inhibitor under evaluation as a potential oral treatment of Acquired Immunodeficiency Diseases. PNU-103017 is a racemic mixture of two enantiomers, designated PNU-103264 (R-) and PNU-103265 (S-). The C
max
(P≤0.0349), C
min
(P≤0.0168), and C
av
(P≤0.0118) are significantly higher for the (R)- than the (S)-enantiomer, showing enantioselective pharmacokinetics of PNU-103017 in the dog.
166335-18-8
上下游产品信息
上游原料
下游产品
166335-18-8, 166335-18-8 相关搜索:
- 抑制剂
- 化合物 PNU-103017
- 化合物 T16555
- 166335-18-8
- PNU103017,PNU 103017
- Benzenesulfonamide, 4-cyano-N-[3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3-yl)methyl]phenyl]-
- PNU 103017