166335-18-8
| 中文名称 | 166335-18-8 |
|---|---|
| 中文同义词 | 化合物 T16555 |
| 英文名称 | PNU 103017 |
| 英文同义词 | PNU 103017;Benzenesulfonamide, 4-cyano-N-[3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3-yl)methyl]phenyl]-;PNU103017,PNU 103017 |
| CAS号 | 166335-18-8 |
| 分子式 | C28H28N2O5S |
| 分子量 | 504.6 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 166335-18-8.mol |
| 结构式 |  |
166335-18-8 性质
| 沸点 | 721.3±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.39±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 4.50±1.00(Predicted) |
PNU-103017 是一种 HIV 蛋白酶抑制剂。
HIV protease
PNU-103017 is a selective HIV aspartyl protease inhibitor under evaluation as a potential oral treatment of Acquired Immunodeficiency Diseases. PNU-103017 is a racemic mixture of two enantiomers, designated PNU-103264 (R-) and PNU-103265 (S-). The C max (P≤0.0349), C min (P≤0.0168), and C av (P≤0.0118) are significantly higher for the (R)- than the (S)-enantiomer, showing enantioselective pharmacokinetics of PNU-103017 in the dog.