CP-10
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- CAS号:
- 2366268-80-4
- 英文名:
- 1,2,3,4,5,6,7,8,9-NONACHLORODECANE
- 英文别名:
- CP-10;1,2,3,4,5,6,7,8,9-NONACHLORODECANE;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[4-[[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]methyl]-1H-1,2,3-triazol-1-yl]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
- 中文名:
- CP-10
- 中文别名:
- CBNumber:
- CB7142721
- 分子式:
- C44H49N13O7
- 分子量:
- 871.94
- MOL File:
- Mol file
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CP-10化学性质
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密度:
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1.55±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 200 mg/mL (229.37 mM)
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形态:
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Solid
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酸度系数(pKa):
-
10.74±0.40(Predicted)
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颜色:
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Light yellow to yellow
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CP-10性质、用途与生产工艺
CP-10 是具有高选择性,特异性和显著的 CDK6 降解潜力 (DC50=2.1 nM) 的 PROTAC。它抑制几种造血细胞癌的增殖,包括多发性骨髓瘤,并且对突变和过表达的 CDK6 仍然可以降解。
CDK6
2.1 nM (DC
50
)
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Cereblon
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CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM in human glioblastoma U251 cells. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC
50
: 50-80 fold).
CP-10 displays a cell inhibition potential in multiple myeloma cell MM.1S (IC
50
≈10 nM) and mantle cell lymphoma cells (in Mino, IC
50
≈8 nM).
CP-10
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-125835 | CP-10 | | 1 mg | 3520元 |
2024/04/30 | HY-125835 | CP-10 CP-10 | 2366268-80-4 | 5mg | 8800元 |
2366268-80-4, CP-10 相关搜索:
- 2366268-80-4
- 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[4-[[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]methyl]-1H-1,2,3-triazol-1-yl]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
- 1,2,3,4,5,6,7,8,9-NONACHLORODECANE
- CP-10