YM-5883
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- CAS号:
- 223499-30-7
- 英文名:
- BTP2
- 英文别名:
- BTP2;BPT2;YM-5883;CS-2404;YM-58483;YM-58483(BTP2);YM58483; YM 58483; BPT2;YM-58483, 10 mM in DMSO;CRAC Channel Inhibitor, BTP2;CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem
- 中文名:
- YM-5883
- 中文别名:
- 化合物YM58483;化合物YM58483,10 MM DMSO 溶液;YM-58483 (CRAC CHANNEL抑制剂,BTP2),CRAC CHANNEL抑制剂;N-(4-(3,5-二(三氟甲基)-1H-吡唑-1-基)苯基)-4-甲基-1,2,3-噻二唑-5-甲酰胺
- CBNumber:
- CB7204025
- 分子式:
- C15H9F6N5OS
- 分子量:
- 421.32
- MOL File:
- 223499-30-7.mol
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YM-5883化学性质
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熔点:
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165-167 °C
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密度:
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1.63±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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酸度系数(pKa):
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10.53±0.70(Predicted)
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形态:
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Solid
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颜色:
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white to beige
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YM-5883性质、用途与生产工艺
YM-58483 是一种有效的 CRAC channels 抑制剂，能够抑制 Ca2+ 信号。
YM-58483 can decrease the levels of P-ERK and P-CREB, without affecting the expression of CD11b and GFAP. YM-58483 also inhibits the release of spinal cord IL-1β, TNF-α, and PGE2. YM-58483 and cyclosporine A inhibits T cell proliferation in a one-way mixed lymphocyte reaction (mLR) with IC
50
values of 330 and 12.7 nM, respectively. YM-58483 inhibits DNP antigen-induced histamine release from and leukotrienes (LTs) production in IgE-primed RBL-2H3 cells, a rat basophilic leukemia cell line, with IC
50
values of 460 and 310 nM, respectively. YM-58483 also inhibits phytohemagglutinin-P (PHA)-stimulated IL-5 and IL-13 production in human peripheral blood cells with IC
50
values of 125 and 148 nM, respectively, which is approximately 5 times less potent than prednisolone. YM-58483 inhibits IL-4 and IL-5 production in a conalbumine-stimulated murine Th2 T cell clone (D10.G4.1), and IL-5 production in phytohemagglutinin-stimulated human whole blood cells with IC
50
values comparable to those reported for its CRAC channel inhibition (around 100 nM).
Intrathecal YM-58483 at the concentration of 300 μM (1.5 nmol) and 1000 μM (10 nmol) produces a significant central analgesic effect on the SNL rats. In the mouse graft-versus-host disease (GVHD) model, YM-58483 (1-30 mg/kg, p.o.) and cyclosporine A (1-30 mg/kg, p.o.) inhibit donor anti-host cytotoxic T lymphocyte (CTL) activity and IFN-γ production, and also reduce the number of donor T cells, especially donor CD8
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T cells, in the spleen. YM-58483 (1-10 mg/kg, p.o.) and cyclosporine A (2, 10 mg/kg, p.o.) inhibit the sheep red blood cell (SRBC)-induced delayed type hypersensitivity (DTH) response. M-58483 (30 mg/kg, p.o.) significantly suppresses ovalbumin (OVA)-induced bronchoconstriction in OVA-sensitized guinea pigs, whereas prednisolone does not. YM-58483 (3-30 mg/kg, p.o.) and prednisolone (100 mg/kg, p.o.) both significantly and completely suppress airway hyperresponsiveness (AHR) caused by OVA exposure. YM-58483 inhibits antigen-induced eosinophil infiltration into airways, and decreases IL-4 and cysteinyl-leukotrienes content in inflammatory airways induced in actively sensitized Brown Norway rats. Orally administered YM-58483 prevents antigen-induced late phase asthmatic broncoconstriction and eosinophil infiltration in actively sensitized guinea pigs.
YM-5883
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2025/02/08 | HY-100831 | YM-5883
YM-58483 | 223499-30-7 | 2mg | 500元 |
| 2025/02/08 | HY-100831 | YM-5883
YM-58483 | 223499-30-7 | 10mM * 1mLin DMSO | 742元 |
223499-30-7, YM-5883 相关搜索:
4,9-二氢-1-(2-甲氧基乙基)-2-甲基-4,9-二氧代-3-(2-吡嗪甲基)-1H-萘并[2,3-D]咪唑溴化物 YM26734 355406-09-6 5,6-二氢-2,3-二甲氧基-6,6-二甲基苯并[7,8]吲哚嗪并[2,3-B]喹喔啉 Ethyl4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate YM-53601 6-氨基-N-[3-[4-(4-吗啉基)吡啶并[3',2':4,5]呋喃并[3,2-D]嘧啶-2-基]苯基]-3-吡啶甲酰胺 124900-72-7 4-甲基-1,2,3-噻重氮-5-甲酰胺
- 合成有机化合物配体
- 抑制剂
- C15H9F6N5OS
- 化合物YM58483,10 MM DMSO 溶液
- YM-58483 (CRAC CHANNEL抑制剂,BTP2),CRAC CHANNEL抑制剂
- N-(4-(3,5-二(三氟甲基)-1H-吡唑-1-基)苯基)-4-甲基-1,2,3-噻二唑-5-甲酰胺
- 化合物YM58483
- 223499-30-7
- YM-58483, 10 mM in DMSO
- YM-58483 (CRAC Channel Inhibitor, BTP2), CRAC channel inhibitor
- inhibit,CRAC Channel,Ca2+ release-activated Ca2+ channels,BTP 2,Calcium release-activated channels,YM58483,Inhibitor,YM-58483,BTP-2
- 1,2,3-Thiadiazole-5-carboxamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-
- CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem
- N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
- CS-2404
- YM58483; YM 58483; BPT2
- BPT2
- YM-5883
- BTP 2, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide
- YM-58483(BTP2)
- CRAC Channel Inhibitor, BTP2
- YM-58483
- 4-methyl-4μ-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide
- N-[4-[3,5-BIS(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]PHENYL]-4-METHYL-1,2,3-THIADIAZOLE-5-CARBOXAMIDE
- BTP2