ARM-390HCL
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- CAS号:
- 209808-47-9
- 英文名:
- AR-M 1000390 hydrochloride
- 英文别名:
- ARM-390;ARM-390HCl;AR-M1000390 HCl;ARM390 Hydrochloride;ARM 390;ARM-390;ARM390;AR-M 1000390 hydrochloride;N,N-Diethyl-4-(phenyl-4-piperidinylideneMethyl)benzaMide Hydrochloride;N,N-Diethyl-4-(phenyl(piperidin-4-ylidene)methyl)benzamide hydrochloride;Benzamide,N,N-diethyl-4-(phenyl-4-piperidinylidenemethyl)-,monohydrochloride;N,N-Diethyl-4-[phenyl(4-piperidinylidene)methyl]benzamide hydroch loride (1:1)
- 中文名:
- ARM-390HCL
- 中文别名:
- 化合物AR-M 1000390 HYDROCHLORIDE;N,N-二乙基-4-(苯基(哌啶-4-亚基)甲基)苯甲酰胺盐酸盐
- CBNumber:
- CB72565926
- 分子式:
- C23H29ClN2O
- 分子量:
- 384.95
- MOL File:
- 209808-47-9.mol
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ARM-390HCL化学性质
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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<38.49mg/ml in DMSO; <38.49mg/ml in H2O
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形态:
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solid
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颜色:
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White
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ARM-390HCL性质、用途与生产工艺
AR-M 1000390 hydrochloride 是一种有效的选择性 δ 阿片受体激动剂，EC50 为 7.2±0.9 nM。
EC50: 7.2±0.9 nM (δ opioid receptor)
AR-M 1000390 (Compound 6a) exhibits the binding affinities (IC
50
) of 0.87±0.23 nM for the δ opioid receptor and extremely high selectivity over the µ receptor (IC
50
=3800±172 nM) and the κ receptor (IC
50
=7470±606 nM). RINm5F cells are treated with AR-M 1000390 (AR-M100390) and Cyclizine for 16-24 h before measurement of intracellular and secreted insulin levels. AR-M 1000390 mediates a dose-dependent decrease in insulin content with a maximal inhibition of ~90% at the highest concentration tested (10 μM).
Rats are treated with 5, 100, and 600 μmol/kg of AR-M 1000390 (AR-M100390) for 3 and/or 7 days; another group of rats treated with 600 μmol/kg of compound are allowed to recover for 14 days. AR-M 1000390 (600 μmol/kg) causes vacuolation in the β-cell of the rat pancreas that is associated with depletion of insulin and hyperglycemia after 7 days of dosing. Treatment of rats with 600 μmol/kg of AR-M 1000390 results in vacuolation of the β-cell of the rat pancreas that is similar to that reported for cyclizine and cyproheptadine.
ARM-390HCL
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-101039A | ARM-390HCL
AR-M 1000390 hydrochloride | 209808-47-9 | 5mg | 990元 |
| 2024/11/08 | HY-101039A | ARM-390HCL
AR-M 1000390 hydrochloride | 209808-47-9 | 10mM * 1mLin DMSO | 1089元 |
209808-47-9, ARM-390HCL 相关搜索:
- API
- Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- 抑制剂
- C23H28N2OHCl
- N,N-二乙基-4-(苯基(哌啶-4-亚基)甲基)苯甲酰胺盐酸盐
- 化合物AR-M 1000390 HYDROCHLORIDE
- 209808-47-9
- Inhibitor,inhibit,AR-M 1000390,AR M 1000390 hydrochloride,Opioid Receptor,ARM 1000390 hydrochloride
- Benzamide,N,N-diethyl-4-(phenyl-4-piperidinylidenemethyl)-,monohydrochloride
- AR-M1000390 HCl
- ARM390 Hydrochloride
- N,N-Diethyl-4-(phenyl(piperidin-4-ylidene)methyl)benzamide hydrochloride
- N,N-Diethyl-4-[phenyl(4-piperidinylidene)methyl]benzamide hydroch loride (1:1)
- ARM 390;ARM-390;ARM390
- ARM-390
- ARM-390HCl
- N,N-Diethyl-4-(phenyl-4-piperidinylideneMethyl)benzaMide Hydrochloride
- AR-M 1000390 hydrochloride