ARM-390HCL
中文名称 | ARM-390HCL |
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中文同义词 | 化合物AR-M 1000390 HYDROCHLORIDE;N,N-二乙基-4-(苯基(哌啶-4-亚基)甲基)苯甲酰胺盐酸盐 |
英文名称 | AR-M 1000390 hydrochloride |
英文同义词 | AR-M 1000390 hydrochloride;N,N-Diethyl-4-(phenyl-4-piperidinylideneMethyl)benzaMide Hydrochloride;ARM-390HCl;ARM-390;ARM 390;ARM-390;ARM390;N,N-Diethyl-4-[phenyl(4-piperidinylidene)methyl]benzamide hydroch loride (1:1);N,N-Diethyl-4-(phenyl(piperidin-4-ylidene)methyl)benzamide hydrochloride;ARM390 Hydrochloride |
CAS号 | 209808-47-9 |
分子式 | C23H29ClN2O |
分子量 | 384.95 |
EINECS号 | |
相关类别 | Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals;API |
Mol文件 | 209808-47-9.mol |
结构式 |
ARM-390HCL 性质
储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
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溶解度 | <38.49mg/ml,溶于 DMSO; <38.49mg/ml,在水中 |
形态 | 固体 |
颜色 | 白色 |
EC50: 7.2±0.9 nM (δ opioid receptor)
AR-M 1000390 (Compound 6a) exhibits the binding affinities (IC 50 ) of 0.87±0.23 nM for the δ opioid receptor and extremely high selectivity over the µ receptor (IC 50 =3800±172 nM) and the κ receptor (IC 50 =7470±606 nM). RINm5F cells are treated with AR-M 1000390 (AR-M100390) and Cyclizine for 16-24 h before measurement of intracellular and secreted insulin levels. AR-M 1000390 mediates a dose-dependent decrease in insulin content with a maximal inhibition of ~90% at the highest concentration tested (10 μM).
Rats are treated with 5, 100, and 600 μmol/kg of AR-M 1000390 (AR-M100390) for 3 and/or 7 days; another group of rats treated with 600 μmol/kg of compound are allowed to recover for 14 days. AR-M 1000390 (600 μmol/kg) causes vacuolation in the β-cell of the rat pancreas that is associated with depletion of insulin and hyperglycemia after 7 days of dosing. Treatment of rats with 600 μmol/kg of AR-M 1000390 results in vacuolation of the β-cell of the rat pancreas that is similar to that reported for cyclizine and cyproheptadine.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-101039A | ARM-390HCL AR-M 1000390 hydrochloride | 209808-47-9 | 5mg | 990元 |
2024/08/19 | HY-101039A | ARM-390HCL AR-M 1000390 hydrochloride | 209808-47-9 | 10mM * 1mLin DMSO | 1089元 |