5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺
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- CAS号:
- 865305-30-2
- 英文名:
- 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
- 英文别名:
- Ro 4;AF 353;CS-2469;CHEMBL526307;AF-353 (Ro-4);CHEMBL526307;AF 353;AF353;5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine;Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353;5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine;2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
- 中文名:
- 5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺
- 中文别名:
- 化合物AF 353;5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺;5-[5-碘-4-甲氧基-2-(1-甲基乙基)苯氧基]-2,4-嘧啶二胺
- CBNumber:
- CB72609596
- 分子式:
- C14H17IN4O2
- 分子量:
- 400.21
- MOL File:
- 865305-30-2.mol
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5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺化学性质
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沸点:
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510.2±60.0 °C(Predicted)
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密度:
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1.619±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 32 mg/mL (79.96 mM)
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形态:
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Solid
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酸度系数(pKa):
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6.89±0.10(Predicted)
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颜色:
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Light brown to brown
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5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺性质、用途与生产工艺
AF-353 (Ro-4) 是一种有效的、选择性的和口服生物利用的 P2X3 receptor 和 P2X2/3 receptor 的拮抗剂,对人P2X3、大鼠P2X3和人P2X2/3的pIC50值分别为8.06、8.05和7.41。
Target | Value |
hP2X3
(Cell-free assay)
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8.06(pIC50)
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rP2X3
(Cell-free assay)
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8.05(pIC50)
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hP2X2/3
(Cell-free assay)
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7.41(pIC50)
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用途
一种p2x3受体拮抗剂。AF353 is a P2X3 receptor antagonist. Antagonism of the P2X3 receptor is one of the potential therapeutic strategies for the management of neuropathic pain because P2X3 receptors are predominantly localized on small to medium diameter C- and Aδ-fiber primary afferent neurons, which are related to the pain-sensing system.
5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-14483 | AF-353 | | 1 mg | 335元 |
2024/08/19 | HY-14483 | 5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺 AF-353 | 865305-30-2 | 5mg | 854元 |
5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺
生产厂家
865305-30-2, 5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺 相关搜索:
- Inhibitors
- 抑制剂
- 合成有机化合物配体
- 小分子抑制剂
- 小分子抑制剂,天然产物
- C14H17IN4O2
- 化合物AF 353
- 5-[5-碘-4-甲氧基-2-(1-甲基乙基)苯氧基]-2,4-嘧啶二胺
- 5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺
- 865305-30-2
- Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353
- 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine
- CHEMBL526307
- CHEMBL526307;AF 353;AF353
- CS-2469
- 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride Ro 4 hydrochloride
- 5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
- AF-353 (Ro-4)
- 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyriMidinediaMine
- Ro 4
- AF 353
- 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-