Chinese english Germany Japanese Korea

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Struktur
865305-30-2
CAS-Nr.
865305-30-2
Englisch Name:
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
Synonyma:
Ro 4;AF 353;CS-2469;CHEMBL526307;AF-353 (Ro-4);CHEMBL526307;AF 353;AF353;5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine;Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353;5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine;2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
CBNumber:
CB72609596
Summenformel:
C14H17IN4O2
Molgewicht:
400.21
MOL-Datei:
865305-30-2.mol
Request For Quotation

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Eigenschaften

Siedepunkt:
510.2±60.0 °C(Predicted)
Dichte
1.619±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMSO : ≥ 32 mg/mL (79.96 mM)
Aggregatzustand
Solid
pka
6.89±0.10(Predicted)
Farbe
Light brown to brown

Sicherheit

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 μM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats.

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 74)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32760 60
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051
 joe@yuhengpharm.com CHINA 21149 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
CR Corporation Lomited
fred.wen@crcorporation.cn CHINA 12069 58
Hong Kong Tiansheng New Material Trading Co., Ltd 		+8617320695765
 zxx@hktiansheng.com China 981 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49739 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
  • 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
  • AF 353
  • Ro 4
  • 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyriMidinediaMine
  • AF-353 (Ro-4)
  • 5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
  • 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride Ro 4 hydrochloride
  • CS-2469
  • CHEMBL526307;AF 353;AF353
  • CHEMBL526307
  • 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine
  • Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353
  • 865305-30-2
  • C14H17IN4O2
  • Inhibitors
Copyright 2019 © ChemicalBook. All rights reserved