1281870-42-5
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- CAS号:
- 1281870-42-5
- 英文名:
- Rhosin (hydrochloride)
- 英文别名:
- Rhosin HCl;G04 HYDROCHLORIDE;Rhosin (hydrochloride);D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride;(R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride;(R,E)-2-Amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride;(2R)-2-amino-3-(1H-indol-3-yl)-N'-[(quinoxalin-6-yl)methylidene]propanehydrazide hydrochloride;plasticity,D1-MSN,MCF7,Apoptosis,hyperexcitability,Rhosin hydrochloride,Ras,stress,Rhosin,selective,inhibit,cells,Inhibitor,resiliency
- 中文名:
- 1281870-42-5
- 中文别名:
- RHOSIN盐酸盐;RHOSIN 游离态;RHO抑制剂(RHOSIN盐酸盐);化合物RHOSIN HYDROCHLORIDE;RHOSIN HYDROCHLORIDE,RHO抑制剂;(R,E)-2-氨基-3-(1H-吲哚-3-基)-N'-(喹喔啉-6-基亚甲基)丙酰肼;(R,E)-2-氨基-3-(1H-吲哚-3-基)-N'-(喹喔啉-6-基亚甲基)丙酰肼盐酸盐;(R,E)-2-氨基-3-(1H-吲哚-3-基)-N'-(喹喔啉-6-基亚甲基)丙酰肼盐酸盐
- CBNumber:
- CB72735536
- 分子式:
- C20H19ClN6O
- 分子量:
- 394.86
- MOL File:
- 1281870-42-5.mol
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1281870-42-5化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 10 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): insol
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形态:
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A solid
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颜色:
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Light yellow to yellow
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1281870-42-5性质、用途与生产工艺
Rhosin (G04) hydrochloride (HCl) 是RhoA亚家族 Rho GTPases 的强效特异性抑制剂，Kd值约为0.4 uM。Rhosin hydrochloride 可诱导细胞凋亡。
| Target | Value |
Rho
(Cell-free assay)
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0.4 μM(Kd)
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Rhosin hydrochloride dose-dependently reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres with an EC
50
~30-50 μM, and causes decreased size and reduced number of mammospheres in MCF7 cells.
Rhosin (40 mg/kg; i.p.) treatment prevents social avoidance caused by social defeat stress. Rhosin also blocks sucrose preference deficits induced by defeat in C57Bl6/J (Jackson) mice.
Rhosin (30 µM; bilateral, intra- Nucleus Accumbens (NAc) infusions) attenuates stress-induced social avoidance. Rhosin blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs). Rhosin prevents decreased excitatory transmission on NAc D1-MSNs. Rhosin enhances spine density in defeat mice.
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Animal Model:
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D1-GFP or D2-GFP hemizygote mice on a C57BL/6J background
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Dosage:
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40 mg/kg
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Administration:
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I.p.
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Result:
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Rhosin was systemically administered 15 min prior to defeat to block RhoA activation. While defeat significantly reduced the time that experimental mice spent interacting with a novel mouse, Rhosin administration suppressed this effect without affecting locomotor behaviors.
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1281870-42-5
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-12646 | Rhosin hydrochloride | | 1 mg | 1600元 |
| 2024/11/08 | HY-12646 | 1281870-42-5
Rhosin hydrochloride | 1281870-42-5 | 2mg | 2330元 |
1281870-42-5, 1281870-42-5 相关搜索:
- 抑制剂
- 药靶配体
- 对照品
- 细胞生物学试剂
- RHOSIN HYDROCHLORIDE,RHO抑制剂
- (R,E)-2-氨基-3-(1H-吲哚-3-基)-N'-(喹喔啉-6-基亚甲基)丙酰肼盐酸盐
- RHOSIN盐酸盐
- (R,E)-2-氨基-3-(1H-吲哚-3-基)-N'-(喹喔啉-6-基亚甲基)丙酰肼
- 化合物RHOSIN HYDROCHLORIDE
- RHOSIN 游离态
- (R,E)-2-氨基-3-(1H-吲哚-3-基)-N'-(喹喔啉-6-基亚甲基)丙酰肼盐酸盐
- RHO抑制剂(RHOSIN盐酸盐)
- 1281870-42-5
- (R,E)-2-Amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride
- plasticity,D1-MSN,MCF7,Apoptosis,hyperexcitability,Rhosin hydrochloride,Ras,stress,Rhosin,selective,inhibit,cells,Inhibitor,resiliency
- (2R)-2-amino-3-(1H-indol-3-yl)-N'-[(quinoxalin-6-yl)methylidene]propanehydrazide hydrochloride
- G04 HYDROCHLORIDE
- D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
- (R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride
- Rhosin HCl
- Rhosin (hydrochloride)