1281870-42-5
| 中文名称 | 1281870-42-5 |
|---|---|
| 中文同义词 | RHO抑制剂(RHOSIN盐酸盐);(R,E)-2-氨基-3-(1H-吲哚-3-基)-N'-(喹喔啉-6-基亚甲基)丙酰肼盐酸盐;RHOSIN 游离态;化合物RHOSIN HYDROCHLORIDE;(R,E)-2-氨基-3-(1H-吲哚-3-基)-N'-(喹喔啉-6-基亚甲基)丙酰肼;RHOSIN盐酸盐;(R,E)-2-氨基-3-(1H-吲哚-3-基)-N'-(喹喔啉-6-基亚甲基)丙酰肼盐酸盐;RHOSIN HYDROCHLORIDE,RHO抑制剂 |
| 英文名称 | Rhosin (hydrochloride) |
| 英文同义词 | Rhosin (hydrochloride);Rhosin HCl;(R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride;D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride;G04 HYDROCHLORIDE;(2R)-2-amino-3-(1H-indol-3-yl)-N'-[(quinoxalin-6-yl)methylidene]propanehydrazide hydrochloride;plasticity,D1-MSN,MCF7,Apoptosis,hyperexcitability,Rhosin hydrochloride,Ras,stress,Rhosin,selective,inhibit,cells,Inhibitor,resiliency;(R,E)-2-Amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride |
| CAS号 | 1281870-42-5 |
| 分子式 | C20H19ClN6O |
| 分子量 | 394.86 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;对照品 |
| Mol文件 | 1281870-42-5.mol |
| 结构式 |  |
1281870-42-5 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMF：10mg/mL； DMSO：5mg/mL；乙醇：5mg/mL； PBS (pH 7.2)：不溶 |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
| Target | Value |
|
Rho
(Cell-free assay) | 0.4 μM(Kd) |
Rhosin hydrochloride dose-dependently reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres with an EC 50 ~30-50 μM, and causes decreased size and reduced number of mammospheres in MCF7 cells.
Rhosin (40 mg/kg; i.p.) treatment prevents social avoidance caused by social defeat stress. Rhosin also blocks sucrose preference deficits induced by defeat in C57Bl6/J (Jackson) mice.
Rhosin (30 µM; bilateral, intra- Nucleus Accumbens (NAc) infusions) attenuates stress-induced social avoidance. Rhosin blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs). Rhosin prevents decreased excitatory transmission on NAc D1-MSNs. Rhosin enhances spine density in defeat mice.
| Animal Model: | D1-GFP or D2-GFP hemizygote mice on a C57BL/6J background |
| Dosage: | 40 mg/kg |
| Administration: | I.p. |
| Result: | Rhosin was systemically administered 15 min prior to defeat to block RhoA activation. While defeat significantly reduced the time that experimental mice spent interacting with a novel mouse, Rhosin administration suppressed this effect without affecting locomotor behaviors. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-12646 | Rhosin hydrochloride | 1 mg | 1600元 | |
| 2024/08/19 | HY-12646 | 1281870-42-5 Rhosin hydrochloride | 1281870-42-5 | 2mg | 2330元 |