GYKI 47261 dihydrochloride
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- CAS号:
- 1217049-32-5
- 英文名:
- GYKI 47261 dihydrochloride
- 英文别名:
- 中文名:
- 中文别名:
- CBNumber:
- CB73037299
- 分子式:
- C18H17Cl3N4
- 分子量:
- 395.71338
- MOL File:
- 1217049-32-5.mol
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GYKI 47261 dihydrochloride化学性质
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溶解度:
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Soluble to 100 mM in DMSO
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形态:
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Powder
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GYKI 47261 dihydrochloride性质、用途与生产工艺
GYKI-47261 dihydrochloride 是一种竞争性、具有口服活性、选择性 AMPA 受体拮抗剂，IC50为 2.5 μM，具有广谱抗惊厥和神经保护作用。GYKI-47261 dihydrochloride 也是 CYP2E1 的有效诱导剂。
GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice.
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP.
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Animal Model:
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Male C57 black mice, weighing 23-30 g
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Dosage:
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20 mg/kg
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Administration:
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I.p.
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Result:
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Reversed the MPTP-induced decrease in striatal concentrations.
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GYKI 47261 dihydrochloride
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