GYKI-47261 DIHYDROCHLORIDE
| 中文名称 | GYKI-47261 DIHYDROCHLORIDE |
|---|---|
| 中文同义词 | |
| 英文名称 | GYKI 47261 dihydrochloride |
| 英文同义词 | |
| CAS号 | 1217049-32-5 |
| 分子式 | C18H17Cl3N4 |
| 分子量 | 395.71338 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1217049-32-5.mol |
| 结构式 |  |
GYKI-47261 DIHYDROCHLORIDE 性质
| 溶解度 | 在 DMSO 中溶解度为 100 mM |
|---|---|
| 形态 | 粉末 |
GYKI-47261 dihydrochloride 是一种竞争性、具有口服活性、选择性 AMPA 受体拮抗剂，IC50为 2.5 μM，具有广谱抗惊厥和神经保护作用。GYKI-47261 dihydrochloride 也是 CYP2E1 的有效诱导剂。
GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice.
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP.
| Animal Model: | Male C57 black mice, weighing 23-30 g |
| Dosage: | 20 mg/kg |
| Administration: | I.p. |
| Result: | Reversed the MPTP-induced decrease in striatal concentrations. |