SRI-011381 (hydrochloride)
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- CAS号:
- 2070014-88-7
- 英文名:
- SRI-011381 (hydrochloride)
- 英文别名:
- SRI-011381 (hydrochloride);SRI 011381 hydrochloride,multiple,Transforming growth factor beta,sclerosis,TGF-beta/Smad,α-SMA,NALP3,SRI 011381,collagen-1,SRI-011381,inhibit,TGF-β,neuroprotective,SRI011381,Inhibitor,SRI011381 hydrochloride
- 中文名:
- SRI-011381 (hydrochloride)
- 中文别名:
- 化合物SRI-011381 HYDROCHLORIDE
- CBNumber:
- CB73146623
- 分子式:
- C20H32ClN3O
- 分子量:
- 365.95
- MOL File:
- 2070014-88-7.mol
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SRI-011381 (hydrochloride)化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 33.33 mg/mL (91.08 mM)
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形态:
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Solid
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颜色:
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White to off-white
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SRI-011381 (hydrochloride)性质、用途与生产工艺
SRI-011381 hydrochloride 是有口服生物活性的 TGF-beta 信号通路的激活剂，具有神经保护作用。
SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.
SRI-011381 hydrochloride (10 μM) eliminates Saikosaponin A (SSA, 30 μM)-induced protective effects on fibroblasts.
SRI-011381 hydrochloride protects mice against kainic acid-induced excitotoxicity and neurodegeneration.
SRI-011381 hydrochloride (10-75 mg/kg; p.o.; 14 days) results in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin.
SRI-011381 hydrochloride (30 mg/kg; i.p.) activates TGF-β signaling in SBE-luciferase bioluminescent reporter mice.
SRI-011381 hydrochloride is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%.
SRI-011381 hydrochloride reduces neurodegeneratio in APP751Lon, Swetransgenic mice.
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Animal Model:
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FBV mice
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Dosage:
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10 mg/kg, 30 mg/kg, 75 mg/kg
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Administration:
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Oral administration; 14 days
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Result:
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Resulted in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin
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SRI-011381 (hydrochloride)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-100347A | SRI-011381 hydrochloride | | 1 mg | 336元 |
| 2024/04/30 | HY-100347A | SRI-011381 (hydrochloride)
SRI-011381 hydrochloride | 2070014-88-7 | 10mM * 1mLin DMSO | 600元 |
SRI-011381 (hydrochloride)
生产厂家
2070014-88-7, SRI-011381 (hydrochloride) 相关搜索:
- 化合物SRI-011381 HYDROCHLORIDE
- 2070014-88-7
- SRI 011381 hydrochloride,multiple,Transforming growth factor beta,sclerosis,TGF-beta/Smad,α-SMA,NALP3,SRI 011381,collagen-1,SRI-011381,inhibit,TGF-β,neuroprotective,SRI011381,Inhibitor,SRI011381 hydrochloride
- SRI-011381 (hydrochloride)