SRI-011381 (hydrochloride)
| 中文名称 | SRI-011381 (hydrochloride) |
|---|---|
| 中文同义词 | 化合物SRI-011381 HYDROCHLORIDE |
| 英文名称 | SRI-011381 (hydrochloride) |
| 英文同义词 | SRI-011381 (hydrochloride);SRI 011381 hydrochloride,multiple,Transforming growth factor beta,sclerosis,TGF-beta/Smad,α-SMA,NALP3,SRI 011381,collagen-1,SRI-011381,inhibit,TGF-β,neuroprotective,SRI011381,Inhibitor,SRI011381 hydrochloride |
| CAS号 | 2070014-88-7 |
| 分子式 | C20H32ClN3O |
| 分子量 | 365.95 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2070014-88-7.mol |
| 结构式 |  |
SRI-011381 (hydrochloride) 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：33.33 mg/mL（91.08 mM） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
TGF-beta
SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.
SRI-011381 hydrochloride (10 μM) eliminates Saikosaponin A (SSA, 30 μM)-induced protective effects on fibroblasts.
SRI-011381 hydrochloride protects mice against kainic acid-induced excitotoxicity and neurodegeneration.
SRI-011381 hydrochloride (10-75 mg/kg; p.o.; 14 days) results in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin.
SRI-011381 hydrochloride (30 mg/kg; i.p.) activates TGF-β signaling in SBE-luciferase bioluminescent reporter mice.
SRI-011381 hydrochloride is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%.
SRI-011381 hydrochloride reduces neurodegeneratio in APP751Lon, Swetransgenic mice.
| Animal Model: | FBV mice |
| Dosage: | 10 mg/kg, 30 mg/kg, 75 mg/kg |
| Administration: | Oral administration; 14 days |
| Result: | Resulted in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100347A | SRI-011381 hydrochloride | 1 mg | 336元 | |
| 2024/04/30 | HY-100347A | SRI-011381 (hydrochloride) SRI-011381 hydrochloride | 2070014-88-7 | 10mM * 1mLin DMSO | 600元 |