他尼氟酯
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- CAS号:
- 66898-62-2
- 英文名:
- Talniflumate
- 英文别名:
- somalgen;ba7602-06;TALNIFLUMATE;Talniflumate, >=99%;Talniflumate (BA 7602-06);TALNIFLUMATE(INTERMEDIATE);phthalidyl2-(3-trifluoromethylanilino)nicotinate;2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid phthalidyl ester;phthalidyl2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinate;2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinicaciphthalidylester
- 中文名:
- 他尼氟酯
- 中文别名:
- 酞尼氟酯;氟尼酸酯;氟烟酞酯;他尼氟酯;他尼氟酯TALNIFLUMATE;2-[(3-三氟甲基)苯基]氨基-3-吡啶羧酸苯酞酯;3-氧代-1,3-二氢异苯并呋喃-1-基 2-((3-(三氟甲基)苯基)氨基)烟酸酯
- CBNumber:
- CB7315594
- 分子式:
- C21H13F3N2O4
- 分子量:
- 414.33
- MOL File:
- 66898-62-2.mol
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他尼氟酯化学性质
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熔点:
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165-167°C
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沸点:
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534.6±50.0 °C(Predicted)
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密度:
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1.49±0.1 g/cm3(Predicted)
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储存条件:
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Store at +4°C
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溶解度:
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Chlorform (Slightly), DMSO (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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2.72±0.10(Predicted)
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形态:
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Solid
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颜色:
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Off-White to Pale Yellow
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最大波长(λmax):
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287nm(CHCl3)(lit.)
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Merck:
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14,9044
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稳定性:
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Acid Sensitive, Moisture Sensitive
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他尼氟酯性质、用途与生产工艺
Talniflumate (MSI-1995)是一种抗炎药,在治疗囊胞性纤维症、慢性阻塞性肺病和哮喘中被用作粘蛋白调节剂。Talniflumate 也是一种人钙激活的氯离子通道chloride channels。
IC50: Ca
2+
-activated Cl
-
channel (CaCC)
Talniflumate (oral chow; 0.4 mg/g; 21 days) significantly increases CF mouse survival from 26 to 77%. It does not alter crypt goblet cell numbers or change intestinal expression of mCLCA3 but tends to decrease crypt mucoid impaction.
Animal Model:
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CF mice with distal intestinal obstructive syndrome (DIOS)
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Dosage:
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0.4 mg/g
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Administration:
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Oral chow; 21 days
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Result:
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Increased survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
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化学性质
白色至淡黄色结晶性粉末。
用途
他尼氟酯为非甾体消炎镇痛原料药,同时可用于纤维性囊肿和哮喘的辅助治疗。
他尼氟酯
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | T3101 | 他尼氟酯 Talniflumate | 66898-62-2 | 200mg | 345元 |
2024/04/30 | S6439 | 他尼氟酯 Talniflumate | 66898-62-2 | 5mg | 795.1元 |
他尼氟酯
生产厂家
全球有 116家供应商
他尼氟酯国内生产厂家
66898-62-2, 他尼氟酯 相关搜索:
- 药靶配体
- 生化试剂
- 医用原料
- 他尼氟酯及中间体
- 生物活性小分子
- C21H13F3N2O4
- 66898-62
- 他尼氟酯TALNIFLUMATE
- 3-氧代-1,3-二氢异苯并呋喃-1-基 2-((3-(三氟甲基)苯基)氨基)烟酸酯
- 酞尼氟酯
- 氟尼酸酯
- 氟烟酞酯
- 他尼氟酯
- 2-[(3-三氟甲基)苯基]氨基-3-吡啶羧酸苯酞酯
- 66898-62-2
- 3-Oxo-1,3-dihydroisobenzofuran-1-yl 2-((3-(trifluoromethyl)phenyl)amino)nicotinate
- Talniflumate (BA 7602-06)
- 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester
- (3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate
- 2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester
- 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl3-pyridinecarboxylicacidester
- 2-[[3-(Trifluoromethyl)phenyl]amino]nicotinic acid 1,3-dihydro-3-oxoisobenzofuran-1-yl ester
- 2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid phthalidyl ester
- TALNIFLUMATE(INTERMEDIATE)
- TALNIFLUMATE
- 3-pyridinecarboxylic acid 2-{[(3-trifluoromethyl)phenyl]amino}-1,3-dihydro-3-oxo-1-soenzofuranyl ester
- 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO]-3-PYRIDINECARBOXYLIC ACID 1,3-DIHYDRO-3-OXO-1-ISOBENZOFURANYL ESTER
- somalgen
- phthalidyl2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinate
- phthalidyl2-(3-trifluoromethylanilino)nicotinate
- ba7602-06
- 2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinicacidphthalidylester
- Talniflumate, >=99%
- 3-phthalidylesterof2-((3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxyl
- 3-ftalidilicodelacido2-((3-(trifluormetil)fenil)amino)-3-piridincarboxilic
- 2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinicaciphthalidylester