205187-35-5
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- CAS号:
- 205187-35-5
- 英文名:
- 2614W94
- 英文别名:
- 2614W94;2614W-94,2614W94;Phenoxathiin, 3-(2,2,2-trifluoro-1-methylethoxy)-, 10,10-dioxide
- 中文名:
- 205187-35-5
- 中文别名:
- 化合物2614W94;化合物 T10089
- CBNumber:
- CB73175519
- 分子式:
- C15H11F3O4S
- 分子量:
- 344.31
- MOL File:
- 205187-35-5.mol
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205187-35-5化学性质
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沸点:
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440.8±45.0 °C(Predicted)
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密度:
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1.449±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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颜色:
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Off-white to light yellow
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205187-35-5性质、用途与生产工艺
2614W94是具有选择性的，可逆的monoamine oxidase-A抑制剂，IC50值和Ki值分别为5 nM和1.6 nM。
IC50: 5 nM (Monoamine Oxidase)
Ki: 1.6 nM (Monoamine Oxidase)
2614W94 shows potent inhibitory activity against MAO-A, but shows no inhibition of MAO-B at 30 nM.
2614W94 (5 mg/kg, p.o.) produces selective inhibition of MAO-A in brains and livers of rats. 2614W94 (5 mg/kg, p.o.) also causes an elevation of neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a concomitant decrease in their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) potentiates 5-hydroxytryptophan-induced head twitches in rats in a dose-dependent manner, with an extrapolated ED
50
of 1.1 mg/kg.
205187-35-5
上下游产品信息
上游原料
下游产品
205187-35-5, 205187-35-5 相关搜索:
- 化合物2614W94
- 化合物 T10089
- 205187-35-5
- 2614W-94,2614W94
- Phenoxathiin, 3-(2,2,2-trifluoro-1-methylethoxy)-, 10,10-dioxide
- 2614W94