205187-35-5
| 中文名称 | 205187-35-5 |
|---|---|
| 中文同义词 | 化合物 T10089;化合物2614W94 |
| 英文名称 | 2614W94 |
| 英文同义词 | 2614W94;Phenoxathiin, 3-(2,2,2-trifluoro-1-methylethoxy)-, 10,10-dioxide;2614W-94,2614W94 |
| CAS号 | 205187-35-5 |
| 分子式 | C15H11F3O4S |
| 分子量 | 344.31 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 205187-35-5.mol |
| 结构式 |  |
205187-35-5 性质
| 沸点 | 440.8±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.449±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
2614W94是具有选择性的，可逆的monoamine oxidase-A抑制剂，IC50值和Ki值分别为5 nM和1.6 nM。
IC50: 5 nM (Monoamine Oxidase)
Ki: 1.6 nM (Monoamine Oxidase)
2614W94 shows potent inhibitory activity against MAO-A, but shows no inhibition of MAO-B at 30 nM.
2614W94 (5 mg/kg, p.o.) produces selective inhibition of MAO-A in brains and livers of rats. 2614W94 (5 mg/kg, p.o.) also causes an elevation of neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a concomitant decrease in their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) potentiates 5-hydroxytryptophan-induced head twitches in rats in a dose-dependent manner, with an extrapolated ED 50 of 1.1 mg/kg.