多柔比星醇
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- CAS号:
- 54193-28-1
- 英文名:
- ADRIAMYCINOL
- 英文别名:
- DOXORUBICINOL;13-dihydrodoxorubicin;RP-27706;ADRIAMYCINOL;antibiotic27706rp;13-dihydroxorubicin;Doxorubicinol (>90%);Doxorubicinol acetate salt;8(r*),10-alpha))-8s-(8-alph;Doxorubicinol-13C D3 citrate
- 中文名:
- 多柔比星醇
- 中文别名:
- 多柔比星醇;多柔比星相关杂质;2H3]-阿霉素醇三氟乙酸盐;13C,2H3]-阿霉素甲酸盐;13C,2H3]-阿霉素三氟乙酸盐;DOXORUBICINOL (>90%)
- CBNumber:
- CB7455328
- 分子式:
- C27H31NO11
- 分子量:
- 545.54
- MOL File:
- 54193-28-1.mol
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多柔比星醇化学性质
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沸点:
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828.7±65.0 °C(Predicted)
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密度:
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1.61±0.1 g/cm3(Predicted)
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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7.49±0.60(Predicted)
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形态:
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Solid
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颜色:
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Red to Very Dark Red
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稳定性:
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Hygroscopic
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多柔比星醇性质、用途与生产工艺
阿霉素为蒽环类广谱抗肿瘤抗生素，其作用机制主要是阿霉素分子进入细胞核与DNA结合，从而抑制核酸的合成和有丝分裂。
盐酸阿霉素具有广谱的抗实验性肿瘤的作用，对拓扑异构酶也有抑制作用，可适用于急性白血病，恶性淋巴瘤，多发性骨髓瘤等。
阿霉素发酵液2000升，加1N的盐酸调pH为1.0进行酸化，酸化3小时后，板框过滤，得预提纯的溶液1650升，经HPLC检测，含阿霉素1000g，色谱含量为16%。预提纯的溶液用100升HP20树脂吸附，吸附完毕后，用300升10%（V/V）的乙醇水溶液，并用盐酸调pH值为2.0作为预洗液，预洗，再用400升50%（V/V）的乙醇水溶液，用盐酸调pH值为2.0作为洗脱液，洗脱，收集合格洗脱液300升。所得洗脱液中含阿霉素800g，色谱含量为79%。
多柔比星醇
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54193-28-1, 多柔比星醇 相关搜索:
- Isotope
- 有机化工原料
- C27H31NO11
- 多柔比星相关杂质
- 13C,2H3]-阿霉素三氟乙酸盐
- 13C,2H3]-阿霉素甲酸盐
- 2H3]-阿霉素醇三氟乙酸盐
- 多柔比星醇
- DOXORUBICINOL (>90%)
- 54193-28-1
- 13C,2H3]-Doxorubicinol formate salt
- 2H3]-Doxorubicinol trifluoroacetate salt
- DOXORUBICINOL
- 13-dihydrodoxorubicin
- DoxorubicinolQ: What is
Doxorubicinol Q: What is the CAS Number of
Doxorubicinol Q: What is the storage condition of
Doxorubicinol Q: What are the applications of
Doxorubicinol
- Doxorubicinol CitrateQ: What is
Doxorubicinol Citrate Q: What is the CAS Number of
Doxorubicinol Citrate Q: What is the storage condition of
Doxorubicinol Citrate
- Doxorubicinol-13C D3 citrate
- Doxorubicinol TFA SaltQ: What is
Doxorubicinol TFA Salt Q: What is the CAS Number of
Doxorubicinol TFA Salt Q: What is the storage condition of
Doxorubicinol TFA Salt
- Doxorubicinol acetate salt
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-[(1S)-1,2-dihydroxyethyl]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
- Doxorubicinol (>90%)
- Doxorubicinol (>90%)
(See also D558020)
- 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-(1,2-dihydroxyethyl)-1-methoxy-6,8,11-trihydroxy-, (8S-(8-alpha,8(R*),10-alpha))-
- RP-27706
- (8S)-7,8,9,10-Tetrahydro-10α-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-[(S)-1,2-dihydroxyethyl]-1-methoxy-6,8α,11-trihydroxy-5,12-naphthacenedione
- 5,12-Naphthacenedione, 10-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-8-(1S)-1,2-dihydroxyethyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
- antibiotic27706rp
- 8(r*),10-alpha))-8s-(8-alph
- 2-dihdyroxyethyl)-1-methoxy-6,8,11-trihydroxy-lyxo-hexopyranosyl)oxy)-8-((
- 13-dihydroxorubicin
- ADRIAMYCINOL