CSF1R-IN-1
|
|
|
- CAS号:
- 2095849-04-8
- 英文名:
- CSF1R-IN-1
- 英文别名:
- CSF1R-IN-1;CSF1R-IN-22;5-(1-Methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide;3-Pyridinecarboxamide, 5-(1-methyl-1H-pyrazol-4-yl)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-;Inhibitor,inhibit,c-Fms,CSF1R IN 1,colony stimulating factor 1 receptor,CSF1RIN1,CSF-1R-IN-1,CSF1R,CSF-1R,CSF-1 receptor
- 中文名:
- CSF1R-IN-1
- 中文别名:
- 化合物CSF1R-IN-1;5-(1-甲基-1H-吡唑-4-基)-N-(2-甲基-5-(3-(三氟甲基)苯甲酰胺基)苯基)烟酰胺
- CBNumber:
- CB74844672
- 分子式:
- C25H20F3N5O2
- 分子量:
- 479.45
- MOL File:
- 2095849-04-8.mol
|
|
|
CSF1R-IN-1化学性质
-
沸点:
-
528.3±50.0 °C(Predicted)
-
|
-
密度:
-
1.34±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系数(pKa):
-
11.58±0.70(Predicted)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
White to off-white
-
|
CSF1R-IN-1性质、用途与生产工艺
CSF1R-IN-1是 CSF1R 的抑制剂，IC50 为0.5 nM。
CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). CSF1R-IN-1 (compound 22) shows good intestinal permeability in a Caco2 assay.
CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept..
|
Animal Model:
|
Male CD-1 mice, 25-35 grams (8-11 weeks old)
|
|
Dosage:
|
2 mg/kg IV or 10 mg/kg orally (Per Os)
|
|
Administration:
|
i.v. or oral
|
|
Result:
|
I.V.: C
max
=3.55, T
1/2
=0.87
P.O.: C
max
=4.6, T
1/2
=1.8, Bioavailability=64%
|
CSF1R-IN-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101774 | CSF1R-IN-1
CSF1R-IN-1 | 2095849-04-8 | 1mg | 1300元 |
| 2024/04/30 | HY-101774 | CSF1R-IN-1
CSF1R-IN-1 | 2095849-04-8 | 5mg | 2700元 |
2095849-04-8, CSF1R-IN-1 相关搜索:
- 化合物CSF1R-IN-1
- 5-(1-甲基-1H-吡唑-4-基)-N-(2-甲基-5-(3-(三氟甲基)苯甲酰胺基)苯基)烟酰胺
- 2095849-04-8
- Inhibitor,inhibit,c-Fms,CSF1R IN 1,colony stimulating factor 1 receptor,CSF1RIN1,CSF-1R-IN-1,CSF1R,CSF-1R,CSF-1 receptor
- 5-(1-Methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide
- 3-Pyridinecarboxamide, 5-(1-methyl-1H-pyrazol-4-yl)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-
- CSF1R-IN-22
- CSF1R-IN-1