CSF1R-IN-1
| 中文名称 | CSF1R-IN-1 |
|---|---|
| 中文同义词 | 5-(1-甲基-1H-吡唑-4-基)-N-(2-甲基-5-(3-(三氟甲基)苯甲酰胺基)苯基)烟酰胺;化合物CSF1R-IN-1 |
| 英文名称 | CSF1R-IN-1 |
| 英文同义词 | CSF1R-IN-1;CSF1R-IN-22;3-Pyridinecarboxamide, 5-(1-methyl-1H-pyrazol-4-yl)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-;5-(1-Methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide;Inhibitor,inhibit,c-Fms,CSF1R IN 1,colony stimulating factor 1 receptor,CSF1RIN1,CSF-1R-IN-1,CSF1R,CSF-1R,CSF-1 receptor |
| CAS号 | 2095849-04-8 |
| 分子式 | C25H20F3N5O2 |
| 分子量 | 479.45 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2095849-04-8.mol |
| 结构式 |  |
CSF1R-IN-1 性质
| 沸点 | 528.3±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.34±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 11.58±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
CSF1R-IN-1是 CSF1R 的抑制剂，IC50 为0.5 nM。
IC50: 0.5 nM (CSF1R)
CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). CSF1R-IN-1 (compound 22) shows good intestinal permeability in a Caco2 assay.
CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept..
| Animal Model: | Male CD-1 mice, 25-35 grams (8-11 weeks old) |
| Dosage: | 2 mg/kg IV or 10 mg/kg orally (Per Os) |
| Administration: | i.v. or oral |
| Result: | I.V.: C max =3.55, T 1/2 =0.87 P.O.: C max =4.6, T 1/2 =1.8, Bioavailability=64% |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-101774 | CSF1R-IN-1 CSF1R-IN-1 | 2095849-04-8 | 1mg | 1300元 |
| 2024/04/30 | HY-101774 | CSF1R-IN-1 CSF1R-IN-1 | 2095849-04-8 | 5mg | 2700元 |