STAT5-IN-2
|
|
|
- CAS号:
- 2111834-61-6
- 英文名:
- STAT5-IN-2
- 英文别名:
- STAT5-IN-2;STAT5 inhibitor 17f;STAT-5-IN-2,STAT5IN2,STAT5 IN 2;Quinoline, 1,2,3,4-tetrahydro-1-[2-(1H-indol-5-yloxy)ethyl]-4,4-dimethyl-6-(3-pyridinyl)-
- 中文名:
- STAT5-IN-2
- 中文别名:
- BUN34616;化合物 T16940;化合物STAT5-IN-2
- CBNumber:
- CB75821403
- 分子式:
- C26H27N3O
- 分子量:
- 397.51
- MOL File:
- 2111834-61-6.mol
|
|
|
STAT5-IN-2化学性质
-
沸点:
-
635.5±55.0 °C(Predicted)
-
|
-
密度:
-
1.160±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO : 100 mg/mL (251.57 mM; Need ultrasonic)
-
|
-
酸度系数(pKa):
-
16.56±0.30(Predicted)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
Off-white to light yellow
-
|
STAT5-IN-2性质、用途与生产工艺
STAT5-IN-2 是 STAT5 的抑制剂，在 K562 和 KU812 细胞中的 EC50 分别为 9 μM和 5 μM，在文献 1 的名称是 17f。STAT5-IN-2 具有高效的抗白血病活性。
|
STAT5
9 μM (EC
50
, in K562 cells)
|
STAT5
5 μM (EC
50
, in KU812 cells )
|
STAT5-IN-2 has EC
50
values of 9 μM and 5 μM in K562 and KU812 cells, respectively.
STAT5-IN-2 (100 nM-50 µM; 48 hours) has EC
50
values of 2.6 µM and 3.5 µM in KG1a and MV-4-11 cells, respectively.
STAT5-IN-2 (10 µM; 48 hours) induces apoptosis in all cell lines (K562, KU812, KG1a and MV-4-11 cells).
STAT5-IN-2 (10 µM; 24 hours) blocks phosphorylation of STAT5.
Cell Viability Assay
|
Cell Line:
|
KG1a and MV-4-11 cell lines
|
|
Concentration:
|
100 nM, 10 µM, 20 µM, 30 µM, 40 µM, 50 µM
|
|
Incubation Time:
|
48 hours
|
|
Result:
|
Inhibited cell growth in KG1a and MV-4-11 cell lines
|
Apoptosis Analysis
|
Cell Line:
|
K562, KU812, KG1a and MV-4-11 cells
|
|
Concentration:
|
10 µM
|
|
Incubation Time:
|
48 hours
|
|
Result:
|
Significantly increased the number of apoptotic cells.
|
Western Blot Analysis
|
Cell Line:
|
KG1a, MV-4-11 and KU812 cells
|
|
Concentration:
|
10 µM
|
|
Incubation Time:
|
24 hours
|
|
Result:
|
Inhibited phosphorylation of STAT5 compared to no influence on phosphorylation level of STAT3, Akt and Erk1/2.
|
STAT5-IN-2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-102048 | STAT5-IN-2 | | 1 mg | 1310元 |
| 2024/08/19 | HY-102048 | STAT5-IN-2
STAT5-IN-2 | 2111834-61-6 | 5mg | 3013元 |
2111834-61-6, STAT5-IN-2 相关搜索:
- 化合物STAT5-IN-2
- BUN34616
- 化合物 T16940
- 2111834-61-6
- STAT-5-IN-2,STAT5IN2,STAT5 IN 2
- Quinoline, 1,2,3,4-tetrahydro-1-[2-(1H-indol-5-yloxy)ethyl]-4,4-dimethyl-6-(3-pyridinyl)-
- STAT5 inhibitor 17f
- STAT5-IN-2