STAT5-IN-2
| 中文名称 | STAT5-IN-2 |
|---|---|
| 中文同义词 | 化合物 T16940;BUN34616;化合物STAT5-IN-2 |
| 英文名称 | STAT5-IN-2 |
| 英文同义词 | STAT5-IN-2;STAT5 inhibitor 17f;Quinoline, 1,2,3,4-tetrahydro-1-[2-(1H-indol-5-yloxy)ethyl]-4,4-dimethyl-6-(3-pyridinyl)-;STAT-5-IN-2,STAT5IN2,STAT5 IN 2 |
| CAS号 | 2111834-61-6 |
| 分子式 | C26H27N3O |
| 分子量 | 397.51 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2111834-61-6.mol |
| 结构式 |  |
STAT5-IN-2 性质
| 沸点 | 635.5±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.160±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：100 mg/mL（251.57 mM；需要超声波） |
| 酸度系数(pKa) | 16.56±0.30(Predicted) |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
STAT5-IN-2 是 STAT5 的抑制剂，在 K562 和 KU812 细胞中的 EC50 分别为 9 μM和 5 μM，在文献 1 的名称是 17f。STAT5-IN-2 具有高效的抗白血病活性。
|
STAT5 9 μM (EC 50 , in K562 cells) |
STAT5 5 μM (EC 50 , in KU812 cells ) |
STAT5-IN-2 has EC
50
values of 9 μM and 5 μM in K562 and KU812 cells, respectively.
STAT5-IN-2 (100 nM-50 µM; 48 hours) has EC
50
values of 2.6 µM and 3.5 µM in KG1a and MV-4-11 cells, respectively.
STAT5-IN-2 (10 µM; 48 hours) induces apoptosis in all cell lines (K562, KU812, KG1a and MV-4-11 cells).
STAT5-IN-2 (10 µM; 24 hours) blocks phosphorylation of STAT5.
Cell Viability Assay
| Cell Line: | KG1a and MV-4-11 cell lines |
| Concentration: | 100 nM, 10 µM, 20 µM, 30 µM, 40 µM, 50 µM |
| Incubation Time: | 48 hours |
| Result: | Inhibited cell growth in KG1a and MV-4-11 cell lines |
Apoptosis Analysis
| Cell Line: | K562, KU812, KG1a and MV-4-11 cells |
| Concentration: | 10 µM |
| Incubation Time: | 48 hours |
| Result: | Significantly increased the number of apoptotic cells. |
Western Blot Analysis
| Cell Line: | KG1a, MV-4-11 and KU812 cells |
| Concentration: | 10 µM |
| Incubation Time: | 24 hours |
| Result: | Inhibited phosphorylation of STAT5 compared to no influence on phosphorylation level of STAT3, Akt and Erk1/2. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-102048 | STAT5-IN-2 | 1 mg | 1310元 | |
| 2024/04/30 | HY-102048 | STAT5-IN-2 STAT5-IN-2 | 2111834-61-6 | 5mg | 3013元 |