Pentagamavunon-1
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- CAS号:
- 27060-70-4
- 英文名:
- Pentagamavunon-1
- 英文别名:
- Pentagamavunon-1;Cyclopentanone, 2,5-bis[(4-hydroxy-3,5-dimethylphenyl)methylene]-
- 中文名:
- Pentagamavunon-1
- 中文别名:
- 化合物 PENTAGAMAVUNON-1
- CBNumber:
- CB76217807
- 分子式:
- C23H24O3
- 分子量:
- 348.43
- MOL File:
- 27060-70-4.mol
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Pentagamavunon-1化学性质
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沸点:
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562.1±50.0 °C(Predicted)
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密度:
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1.232±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 50 mg/mL (143.50 mM)
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酸度系数(pKa):
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10.12±0.40(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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Pentagamavunon-1性质、用途与生产工艺
Pentagamavunon-1 (PGV-1) 是Curcumin 的类似物，具有口服活性，通过多个机制诱导凋亡信号，如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。
Pentagamavunon-1 (PGV-1, 1, 2.5, 5, 7.5, 10, 15, and 20 µM) enhances cytotoxic effect of 5-FU on WiDr cells.
Pentagamavunon-1 (PGV-1, 1, 2.5, 5, and 10 µM) shows different effects on cell cycle progression and induces G2/M arrest.
Cell Viability Assay.
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Cell Line:
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Human colon carcinoma WiDr.
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Concentration:
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1, 2.5, 5, 7.5, 10, 15, and 20 µM.
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Incubation Time:
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6, 12, 24, and 48 hours.
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Result:
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Significantly enhanced the cytotoxicity of 5-FU on WiDr cells at various concentrations during 6, 12, 24, and 48 h incubation.
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Cell Cycle Analysis.
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Cell Line:
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WiDr cells.
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Concentration:
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1, 2.5, 5, and 10 µM.
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Incubation Time:
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24 h.
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Result:
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The non-treated WiDr cells showed cell accumulation in G1, S, and G2/M phase about 50.85%, 36.11% and 13.04%, respectively.
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Pentagamavunon-1 (PGV-1, po, 20 mg/kg) exhibits significant anti-tumor activity in PDX model, without obvious toxicity.
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Animal Model:
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Human cancer cells in a xenograf mouse model.
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Dosage:
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20mg/kg.
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Administration:
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P.O. every 2 days for 20 days.
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Result:
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Exhibited little decrease in body weight, nor a decrease in white and red blood cell counts in peripheral blood, nor any other efects in behavior and macroscopic appearance. Thus,
PGV-1 was sufciently potent to suppress tumor formation in vivo, but exhibited little or no obvious adverse effects on the normal lineage of cells.
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Pentagamavunon-1
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-136477 | Pentagamavunon-1 | | 5 mg | 600元 |
| 2024/08/19 | HY-136477 | Pentagamavunon-1
Pentagamavunon-1 | 27060-70-4 | 10mM * 1mLin DMSO | 660元 |
27060-70-4, Pentagamavunon-1 相关搜索:
- 化合物 PENTAGAMAVUNON-1
- 27060-70-4
- Cyclopentanone, 2,5-bis[(4-hydroxy-3,5-dimethylphenyl)methylene]-
- Pentagamavunon-1